Atlases of the human brain have an important impact on neuroscience. The emergence of
ever more sophisticated imaging techniques, brain mapping methods and analytical …

We review recent developments in brain mapping and computational anatomy that have
greatly expanded our ability to analyze brain structure and function. The enormous diversity …

Motivated by the vast amount of information that is rapidly accumulating about the human
brain in digital form, we embarked upon a program in 1992 to develop a four–dimensional …

Background The ε 4 allele of the apolipoprotein E gene (APOE) is the chief known genetic
risk factor for Alzheimer's disease, the most common cause of dementia late in life. To …

We report the first detailed population-based maps of cortical gray matter loss in Alzheimer's
disease (AD), revealing prominent features of early structural change. New computational …

Fourteen patients with stable acquired brain injuries exhibiting attention and working
memory deficits were given 10 weeks of attention process training (APT) and 10 weeks of …

Noninvasive brain imaging methods provide useful information on cerebral involution and
degenerative processes. Here we assessed cortical degeneration in 20 nondemented …

Figure copy is the most common method of visual spatial assessment in dementia
evaluations, but performance on this test may be multifactorial. We examined the …

Surface registration between cortical surfaces is crucial in medical imaging for performing
systematic comparisons between brains. Landmark-matching registration that matches …

Background: Magnetic resonance imaging (MRI) of hippocampal atrophy is a sensitive but
not specific method to support the clinical diagnosis of early Alzheimer's disease (AD). We …