What is holding back the development of antiviral metallodrugs? A literature overview and implications for SARS-CoV-2 therapeutics and future viral outbreaks

REF de Paiva, AM Neto, IA Santos, ACG Jardim… - Dalton …, 2020 - pubs.rsc.org
In light of the Covid-19 outbreak, this review brings together historical and current literature
efforts towards the development of antiviral metallodrugs. Classical compounds such as …

Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds

ET Papish, OE Oladipupo - Current opinion in chemical biology, 2022 - Elsevier
This review focuses on light-activated ruthenium anticancer compounds and the factors that
influence which pathway is favored. Photodynamic therapy (PDT) is favored by π expansion …

Increasing the π-expansive ligands in ruthenium (II) polypyridyl complexes: synthesis, characterization, and biological evaluation for photodynamic therapy …

MD Pozza, P Mesdom, A Abdullrahman… - Inorganic …, 2023 - ACS Publications
Lack of selectivity is one of the main issues with currently used chemotherapies, causing
damage not only to altered cells but also to healthy cells. Over the last decades …

Ir (III) Half-Sandwich Photosensitizers with a π-Expansive Ligand for Efficient Anticancer Photodynamic Therapy

C Gonzalo-Navarro, E Zafon, JA Organero… - Journal of Medicinal …, 2024 - ACS Publications
One approach to reduce the side effects of chemotherapy in cancer treatment is
photodynamic therapy (PDT), which allows spatiotemporal control of the cytotoxicity. We …

Ru (II)‐Cyanine Complexes as Promising Photodynamic Photosensitizers for the Treatment of Hypoxic Tumours with Highly Penetrating 770 nm Near‐Infrared Light

A Gandioso, E Izquierdo‐García… - … A European Journal, 2023 - Wiley Online Library
Light‐activated treatments, such as photodynamic therapy (PDT), provide temporal and
spatial control over a specific cytotoxic response by exploiting toxicity differences between …

Towards Selective Delivery of a Ruthenium (II) Polypyridyl Complex‐Containing Bombesin Conjugate into Cancer Cells

MJSA Silva, R Vinck, Y Wang, B Saubaméa… - …, 2023 - Wiley Online Library
An increasing number of novel Ru (II) polypyridyl complexes have been successfully applied
as photosensitizers (PSs) for photodynamic therapy (PDT). Despite recent advances in …

Phototoxicity of Tridentate Ru (II) Polypyridyl Complex with Expanded Bite Angles toward Mammalian Cells and Multicellular Tumor Spheroids

RC Curley, CS Burke, KS Gkika, S Noorani… - Inorganic …, 2023 - ACS Publications
Tridentate ligand-coordinated ruthenium (II) polypyridyl complexes with large N–Ru–N bite
angles have been shown to promote ligand field splitting and reduce singlet–triplet state …

Comprehensive picture of the excited state dynamics of Cu (I)-and Ru (II)-based photosensitizers with long-lived triplet states

MA Argüello Cordero, PJ Boden… - Inorganic …, 2021 - ACS Publications
Ru (II)-and Cu (I)-based photosensitizers featuring the recently developed biipo ligand (16H-
benzo-[4′, 5′]-isoquinolino-[2′, 1′,: 1, 2]-imidazo-[4, 5-f]-[1, 10]-phenanthrolin-16-one) …

pH-Responsive luminescence sensing, photoredox catalysis and photodynamic applications of ruthenium (II) photosensitizers bearing imidazo [4, 5-f][1, 10] …

S Kumar, S Singh, A Kumar, KSR Murthy… - Coordination Chemistry …, 2022 - Elsevier
Ru (II)-polypyridyl complexes supported with imidazo [4, 5-f][1, 10] phenanthroline ligand are
of increasing interest as photosensitizers in different research areas. A combination of rich …

Photoactivatable Ruthenium Complexes Containing Minimal Straining Benzothiazolyl-1, 2, 3-triazole Chelators for Cancer Treatment

FJ Ballester, A Hernández-García… - Inorganic …, 2024 - ACS Publications
Ruthenium (II) complexes containing diimine ligands have contributed to the development of
agents for photoactivated chemotherapy. Several approaches have been used to obtain …