Obesity is accompanied by a systemic chronic low-grade inflammation as well as
dysfunctions of several innate and adaptive immune cells. Recent findings emphasize an …

Natural killer (NK) cells are a population of lymphocytes which classically form part of the
innate immune system. They are defined as innate lymphocytes, due to their ability to kill …

Natural killer (NK) cells are the key immune effectors with the ability to mediate selection and
differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and …

Introduction and methods In this study we report that sequential treatment of supercharged
NK (sNK) cells with either chemotherapeutic drugs or check-point inhibitors eliminate both …

We have recently shown that natural killer (NK) cells select and differentiate cancer stem
cells (CSCs)/undifferentiated tumors via secreted and membrane bound IFN-gamma (IFN-γ) …

Background and Aims: We have previously demonstrated that the stage of differentiation of
tumors has profound effect on the function of NK cells, and that stem-like/poorly …

Macrophages are main players of the innate immune system. They show great
heterogeneity and play diverse functions that include support to development, sustenance of …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor outcomes due
to frequent recurrence, metastasis, and resistance to treatment. A major contributor to this …

The most frequent mutated oncogene family in the history of human cancer is the RAS gene
family, including NRAS, HRAS, and, most importantly, KRAS. A hallmark of pancreatic …

Osteoclasts (OCs) and much less dendritic cells (DCs) induce significant expansion and
functional activation of NK cells, and furthermore, the OC-expanded NK cells preferentially …