Tactile sensory information from facial whiskers provides nocturnal tunnel-dwelling rodents,
including mice and rats, with important spatial and textural information about their immediate …

The cerebral vascular system services the constant demand for energy during neuronal
activity in the brain. Attempts to delineate the logic of neurovascular coupling have been …

Activity in motor cortex predicts specific movements seconds before they occur, but how this
preparatory activity relates to upcoming movements is obscure. We dissected the conversion …

Perceptual decisions involve distributed cortical activity. Does information flow sequentially
from one cortical area to another, or do networks of interconnected areas contribute at the …

The posterior parietal cortex (PPC) has an important role in many cognitive behaviours;
however, the neural circuit dynamics underlying PPC function are not well understood. Here …

Many theories of brain function propose that activity in sparse subsets of neurons underlies
perception and action. To place a lower bound on the amount of neural activity that can be …

Neural computation involves diverse types of GABAergic inhibitory interneurons that are
integrated with excitatory (E) neurons into precisely structured circuits. To understand how …

The mouse is an increasingly prominent model for the analysis of mammalian neuronal
circuits. Neural circuits ultimately have to be probed during behaviors that engage the …

Inhibitory interneurons are essential components of the neural circuits underlying various
brain functions. In the neocortex, a large diversity of GABA (γ-aminobutyric acid) …

Comprehensive measurement of neural activity remains challenging due to the large
numbers of neurons in each brain area. We used volumetric two-photon imaging in mice …