The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …

We conducted a genome-wide association study of pancreatic cancer in 3,851 affected
individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies …

The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes
breast cancer cell proliferation, survival, migration and tumour growth. Here we show that, in …

RNA interference currently offers new opportunities for gene therapy by the specific
extinction of targeted gene (s) in cancer diseases. However, the main challenge for nucleic …

Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are
very limited and the underlying mechanisms are poorly understood. We report that bone …

Cervical cancer (CC) is the fourth leading cause of deaths in gynecological malignancies.
Although the etiology of CC has been extensively investigated, the exact pathogenesis of …

Right heart failure is the cause of death of most patients with severe pulmonary arterial
hypertensive (PAH) disorders, yet little is known about the cellular and molecular causes of …

The Kruppel-like factor 5 (KLF5) transcription factor is highly expressed in high-grade and
basal-like breast cancers. However, the mechanism by which KLF5 promotes cell migration …

Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …