Epigenetics and epigenomics in diabetic kidney disease and metabolic memory

M Kato, R Natarajan - Nature Reviews Nephrology, 2019 - nature.com
The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …

Cardiac and Renal Effects of Sodium-Glucose Co-Transporter 2 Inhibitors in Diabetes: JACC State-of-the-Art Review

TA Zelniker, E Braunwald - Journal of the American College of Cardiology, 2018 - jacc.org
Patients with type 2 diabetes mellitus have an increased risk for the development of cardiac
and other vascular events, heart failure (HF), and decline in renal function. After several …

Pathophysiology of mesangial expansion in diabetic nephropathy: mesangial structure, glomerular biomechanics, and biochemical signaling and regulation

HY Thomas, AN Ford Versypt - Journal of Biological Engineering, 2022 - Springer
Diabetic nephropathy, a kidney complication arising from diabetes, is the leading cause of
death in diabetic patients. Unabated, the growing epidemic of diabetes is increasing …

Advanced glycation end-products: a review

R Singh, A Barden, T Mori, L Beilin - Diabetologia, 2001 - Springer
Advanced glycation end-products are a complex and heterogeneous group of compounds
that have been implicated in diabetes related complications. At present it is not known if they …

Diabetic nephropathy—emerging epigenetic mechanisms

M Kato, R Natarajan - Nature Reviews Nephrology, 2014 - nature.com
Diabetic nephropathy (DN), a severe microvascular complication frequently associated with
both type 1 and type 2 diabetes mellitus, is a leading cause of renal failure. The condition …

Protein kinase C activation and the development of diabetic complications.

D Koya, GL King - Diabetes, 1998 - Am Diabetes Assoc
Recent studies have identified that the activation of protein kinase C (PKC) and increased
diacylglycerol (DAG) levels initiated by hyperglycemia are associated with many vascular …

The role of oxidative stress in the onset and progression of diabetes and its complications: asummary of a Congress Series sponsored byUNESCO‐MCBN, the …

P Rösen, PP Nawroth, G King, W Möller… - Diabetes/metabolism …, 2001 - Wiley Online Library
This review summarises the results and discussions of an UNESCO‐MCBN supported
symposium on oxidative stress and its role in the onset and progression of diabetes. There is …

The pathogenesis of diabetic nephropathy

S Dronavalli, I Duka, GL Bakris - Nature clinical practice Endocrinology …, 2008 - nature.com
Abstract Between 20% and 40% of patients with diabetes ultimately develop diabetic
nephropathy, which in the US is the most common cause of end-stage renal disease …

Morphologic changes in the peritoneal membrane of patients with renal disease

JD Williams, KJ Craig, N Topley… - Journal of the …, 2002 - journals.lww.com
This study examined the morphologic features of the parietal peritoneal membranes of 130
patients undergoing peritoneal dialysis (PD) and compared them with the features of the …

Extracellular matrix metabolism in diabetic nephropathy

RM Mason, NA Wahab - Journal of the American Society of …, 2003 - journals.lww.com
Diabetic nephropathy is characterized by excessive deposition of extracellular matrix
proteins in the mesangium and basement membrane of the glomerulus and in the renal …