Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are widespread enzymes in all life kingdoms with
five distinct genetic families known to date, the α-, β-, γ-, δ-and ζ-CAs. With the exception of …

Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as antiglaucoma
agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and …

In 1980 sulfamic acid and its N-substituted derivatives were reviewed in Chemical Reviews,
1 effectively updating an earlier 1940 review 2 also in Chemical Reviews. In 1991 the …

A series of flavonoids, such as quercetin, catechin, apigenin, luteolin, morin, were
investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA) …

Introduction: In the field of medicinal chemistry, there is a growing interest in the use of small
molecules. Although acetyl salicylic acid is well known for medical applications, little is …

A new series of chiral thiourea derivatives (5a–5c) and thiourea containing benzimidazole
moieties (9b–9e) were synthesized from different amino acids (l-valine, l-isoleucine, l …

Abstract Carbonic anhydrase (EC 4.2. 1.1; CA) was purified and characterized from the liver
of the teleost fish Dicentrarchus labrax (European seabass) for the first time. The purification …

The carbonic anhydrases (CAs; EC 4.2. 1.1) are a family of metalloenzymes that catalyze the
reversible hydration of carbon dioxide (CO 2) and dehydration of bicarbonate (HCO 3−) in a …

Carbonic anhydrase inhibitors of primary sulfonamide type, RSO2NH2, have clinical
applications as diuretics, antiglaucoma, antiepileptic, antiobesity and antitumor drugs. Here …