The multifaceted role of reactive oxygen species in tumorigenesis
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …
various normal cellular functions including cellular growth, differentiation, senescence …
The CXCL12-CXCR4/CXCR7 axis as a mechanism of immune resistance in gastrointestinal malignancies
SK Daniel, YD Seo, VG Pillarisetty - Seminars in cancer biology, 2020 - Elsevier
Single agent checkpoint inhibitor therapy has not been effective for most gastrointestinal
solid tumors, but combination therapy with drugs targeting additional immunosuppressive …
solid tumors, but combination therapy with drugs targeting additional immunosuppressive …
Recent advances in phytochemical based nano-drug delivery systems to combat breast cancer: A review
Breast Cancer is the most common cancer in women worldwide. Recently bioactive plant
products, namely phytochemicals are being been explored by researchers for their …
products, namely phytochemicals are being been explored by researchers for their …
Thymoquinone inhibits bone metastasis of breast cancer cells through abrogation of the CXCR4 signaling axis
MK Shanmugam, KS Ahn, A Hsu, CC Woo… - Frontiers in …, 2018 - frontiersin.org
Overexpression of chemokine receptor type 4 (CXCR4) has been found to be associated
with increased cell proliferation, metastasis and also act as an indicator of poor prognosis in …
with increased cell proliferation, metastasis and also act as an indicator of poor prognosis in …
FBXW7 in cancer: what has been unraveled thus far?
The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene FBXW7 is one of the
crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in …
crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in …
Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer
D Shrimali, MK Shanmugam, AP Kumar, J Zhang… - Cancer letters, 2013 - Elsevier
Abstract Emodin (1, 3, 8-trihydroxy-6-methylanthraquinone) is a natural occurring
anthraquinone derivative isolated from roots and barks of numerous plants, molds, and …
anthraquinone derivative isolated from roots and barks of numerous plants, molds, and …
Baicalein: A metabolite with promising antineoplastic activity
Cancer, being a multifactorial disease has diverse presentation in different subgroups which
is mainly attributed to heterogenous presentation of tumor cells. This cancer cell …
is mainly attributed to heterogenous presentation of tumor cells. This cancer cell …
Nimbolide-induced oxidative stress abrogates STAT3 signaling cascade and inhibits tumor growth in transgenic adenocarcinoma of mouse prostate model
J Zhang, KS Ahn, C Kim, MK Shanmugam… - Antioxidants & redox …, 2016 - liebertpub.com
Abstract Aims: Prostate cancer (PCa) is one of the most commonly diagnosed cancers
worldwide. Currently available therapies for metastatic PCa are only marginally effective …
worldwide. Currently available therapies for metastatic PCa are only marginally effective …
Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
M Homayoonfal, Z Asemi, B Yousefi - Cellular & Molecular Biology Letters, 2022 - Springer
Despite great advances, therapeutic approaches of osteosarcoma, the most prevalent class
of preliminary pediatric bone tumors, as well as bone-related malignancies, continue to …
of preliminary pediatric bone tumors, as well as bone-related malignancies, continue to …
Emerging role of plumbagin: Cytotoxic potential and pharmaceutical relevance towards cancer therapy
Plumbagin is a naphthoquinone derived yellow crystalline phytochemical. Plumbagin has a
wide range of biological effects including cytotoxicity against cancer cells both in vitro and in …
wide range of biological effects including cytotoxicity against cancer cells both in vitro and in …