Small animal radiotherapy research platforms

F Verhaegen, P Granton… - Physics in Medicine & …, 2011 - iopscience.iop.org
Advances in conformal radiation therapy and advancements in pre-clinical radiotherapy
research have recently stimulated the development of precise micro-irradiators for small …

Nanoparticles in cancer imaging and therapy

L Smith, Z Kuncic, K Ostrikov… - Journal of …, 2012 - Wiley Online Library
Nanoparticle contrast agents offer the potential to significantly improve existing methods of
cancer diagnosis and treatment. Advantages include biocompatibility, selective …

Increased apoptotic potential and dose‐enhancing effect of gold nanoparticles in combination with single‐dose clinical electron beams on tumor‐bearing mice

MY Chang, AL Shiau, YH Chen, CJ Chang… - Cancer …, 2008 - Wiley Online Library
High atomic number material, such as gold, may be used in conjunction with radiation to
provide dose enhancement in tumors. In the current study, we investigated the dose …

Estimation of microscopic dose enhancement factor around gold nanoparticles by Monte Carlo calculations

BL Jones, S Krishnan, SH Cho - Medical physics, 2010 - Wiley Online Library
Purpose An approach known as gold nanoparticle‐aided radiation therapy (GNRT) is a
recent development in radiation therapy which seeks to make a tumor more susceptible to …

The dosimetric feasibility of gold nanoparticle-aided radiation therapy (GNRT) via brachytherapy using low-energy gamma-/x-ray sources

SH Cho, BL Jones, S Krishnan - Physics in Medicine & Biology, 2009 - iopscience.iop.org
The preferential accumulation of gold nanoparticles within tumors and the increased
photoelectric absorption due to the high atomic number of gold cooperatively account for the …

Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma

P Liu, H Jin, Z Guo, J Ma, J Zhao, D Li… - International journal of …, 2016 - Taylor & Francis
Radiotherapy performs an important function in the treatment of cancer, but resistance of
tumor cells to radiation still remains a serious concern. More research on more effective …

Characterization of the theorectical radiation dose enhancement from nanoparticles

JC Roeske, L Nunez, M Hoggarth… - … in cancer research …, 2007 - journals.sagepub.com
Recently, nanoparticles have been considered as a method of providing radiation dose
enhancement in tumors. In order to quantify this affect, a dose enhancement factor (DEF) is …

[HTML][HTML] Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles

JC Polf, LF Bronk, WHP Driessen, W Arap… - Applied physics …, 2011 - pubs.aip.org
The development and use of sensitizing agents to improve the effectiveness of radiotherapy
have long been sought to improve our ability to treat cancer. In this letter, we have studied …

The effect of contrast material on radiation dose at CT: part II. A systematic evaluation across 58 patient models

P Sahbaee, E Abadi, WP Segars, D Marin, RC Nelson… - Radiology, 2017 - pubs.rsna.org
Purpose To estimate the radiation dose as a result of contrast medium administration in a
typical abdominal computed tomographic (CT) examination across a library of contrast …

Quantifying tumor-selective radiation dose enhancements using gold nanoparticles: a monte carlo simulation study

SX Zhang, J Gao, TA Buchholz, Z Wang… - Biomedical …, 2009 - Springer
Gold nanoparticles can enhance the biological effective dose of radiation delivered to
tumors, but few data exist to quantify this effect. The purpose of this project was to build a …