There is an avalanche of biomedical data generation and a parallel expansion in
computational capabilities to analyze and make sense of these data. Starting with genome …

Mass spectrometry (MS) instruments and experimental protocols are rapidly advancing, but
the software tools to analyse tandem mass spectra are lagging behind. We present a …

Proteins with up to 100 amino acids have been largely overlooked due to the challenges
associated with predicting and identifying them using traditional methods. Recent advances …

In the preceding decades, molecular characterization has revolutionized breast cancer (BC)
research and therapeutic approaches. Presented herein, an unbiased analysis of breast …

The complexity of the functional proteome extends considerably beyond the coding genome,
resulting in millions of proteoforms. Investigation of proteoforms and their functional roles is …

Immunopeptidomics aims to identify major histocompatibility complex (MHC)-presented
peptides on almost all cells that can be used in anti-cancer vaccine development. However …

COVID-19 is characterised by systemic immunological perturbations in the human body,
which can lead to multi-organ damage. Many of these processes are considered to be …

Hyperdiploidy, ie gain of whole chromosomes, is one of the most common genetic features
of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly …

Environmental cues, such as physical forces and heterotypic cell interactions play a critical
role in cell function, yet their collective contributions to transcriptional changes are unclear …

Bacteria must balance the different needs for substrate assimilation, growth functions, and
resilience in order to thrive in their environment. Of all cellular macromolecules, the bacterial …