Tau biomarkers in Alzheimer's disease: towards implementation in clinical practice and trials

R Ossenkoppele, R van der Kant… - The Lancet …, 2022 - thelancet.com
Background Deposition of tau aggregates is a pathological hallmark of Alzheimer's disease
that is closely linked both spatially and temporally to emergence of neurodegeneration and …

Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility

TK Karikari, NJ Ashton, G Brinkmalm… - Nature Reviews …, 2022 - nature.com
Well-authenticated biomarkers can provide critical insights into the biological basis of
Alzheimer disease (AD) to enable timely and accurate diagnosis, estimate future burden and …

Specific associations between plasma biomarkers and postmortem amyloid plaque and tau tangle loads

G Salvadó, R Ossenkoppele, NJ Ashton… - EMBO molecular …, 2023 - embopress.org
Several promising plasma biomarkers for Alzheimer's disease have been recently
developed, but their neuropathological correlates have not yet been fully determined. To …

[HTML][HTML] Plasma phospho-tau in Alzheimer's disease: towards diagnostic and therapeutic trial applications

F Gonzalez-Ortiz, PR Kac, WS Brum… - Molecular …, 2023 - Springer
As the leading cause of dementia, Alzheimer's disease (AD) is a major burden on affected
individuals, their families and caregivers, and healthcare systems. Although AD can be …

[HTML][HTML] Sex differences in plasma p-tau181 associations with Alzheimer's disease biomarkers, cognitive decline, and clinical progression

AA Tsiknia, SD Edland, EE Sundermann, ET Reas… - Molecular …, 2022 - nature.com
Studies have shown that women on the Alzheimer's disease (AD) continuum have more
pathological tau in the brain and cerebrospinal fluid (CSF), than men. Some studies have …

Equivalence of plasma p‐tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease

J Therriault, S Servaes, C Tissot… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION Plasma biomarkers are promising tools for Alzheimer's disease (AD)
diagnosis, but comparisons with more established biomarkers are needed. METHODS We …

Fluid biomarkers in Alzheimer's disease

J Simrén, A Elmgren, K Blennow… - Advances in clinical …, 2023 - Elsevier
Alzheimer's disease (AD) characterization has progressed from being indexed using clinical
symptomatology followed by neuropathological examination at autopsy to in vivo signatures …

Sensitive detection of multiple blood biomarkers via immunomagnetic exosomal PCR for the diagnosis of Alzheimer's disease

S Hu, L Zhang, Y Su, X Liang, J Yang, Q Luo… - Science …, 2024 - science.org
Blood exosomes are emerging as potential biomarkers for diagnosing brain diseases such
as Alzheimer's disease (AD). There is currently a lack of an ultrasensitive technology for …

[HTML][HTML] Portable vertical graphene@ Au-based electrochemical aptasensing platform for point-of-care testing of tau protein in the blood

Y Liu, X Liu, M Li, Q Liu, T Xu - Biosensors, 2022 - mdpi.com
Alzheimer's disease (AD) is a long-term neurodegenerative disease that poses a serious
threat to human life and health. It is very important to develop a portable quantitative device …

[HTML][HTML] Tau; one protein, so many diseases

P Tabeshmehr, E Eftekharpour - Biology, 2023 - mdpi.com
Simple Summary Tau is an important protein for maintaining the shape and normal function
of nerve cells. There are many diseases that are identified by changes in this protein, yet …