We have developed workflows to align 3D magnetic resonance histology (MRH) of the
mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen …

Understanding amazingly complex brain functions and pathologies requires a complete
cerebral vascular atlas in stereotaxic coordinates. Making a precise atlas for cerebral …

The development of methods for imaging large contiguous volumes with the electron
microscope could allow the complete mapping of a whole mouse brain at the single-axon …

Figure 1| From multi-modal connectivity data to integrated connectomes. Image panels
illustrating recent progress, selected and modified from contributions to the Research Topic …

Techniques based on imaging serial sections of brain tissue provide insight into brain
structure and function. However, to compare or combine them with results from three …

The brain is organized on multiple levels. The lowest meaningful one pertains to the
molecular realm, followed by subcellular structures like the synapses, by cells like the …

This detailed protocol outlines the implementation of image-guided, laser-based hydrogel
degradation for the fabrication of vascular-derived microfluidic networks embedded in …

Mapping the microvascular networks in the brain can lead to significant scientific and clinical
insights. We developed a serial sectioning microscopy technique called the Knife-Edge …

Serial section microscopy has proven to be a powerful tool in examining the 3-dimensional
(3D) nature of tissue; however, it is limited by the size of tissue samples that can be used …

We analyze the scaling and cost-performance characteristics of current and projected
connectomics approaches, with reference to the potential implications of recent advances in …