A guide to the organ-on-a-chip

CM Leung, P De Haan… - Nature Reviews …, 2022 - nature.com
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

Drug delivery across the blood–brain barrier: recent advances in the use of nanocarriers

JJE Mulvihill, EM Cunnane, AM Ross, JT Duskey… - …, 2020 - Taylor & Francis
The blood–brain barrier (BBB) has a significant contribution to homeostasis and protection
of the CNS. However, it also limits the crossing of therapeutics and thereby complicates the …

Tumor spheroid-on-a-chip: a standardized microfluidic culture platform for investigating tumor angiogenesis

J Ko, J Ahn, S Kim, Y Lee, J Lee, D Park, NL Jeon - Lab on a Chip, 2019 - pubs.rsc.org
The field of microfluidics-based three-dimensional (3D) cell culture system is rapidly
progressing from academic proof-of-concept studies to valid solutions to real-world …

Advances in microfluidic in vitro systems for neurological disease modeling

PM Holloway, S Willaime‐Morawek… - Journal of …, 2021 - Wiley Online Library
Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

Microfluidics for neuronal cell and circuit engineering

R Habibey, JE Rojo Arias, J Striebel… - Chemical …, 2022 - ACS Publications
The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

3D brain angiogenesis model to reconstitute functional human blood–brain barrier in vitro

S Lee, M Chung, SR Lee… - Biotechnology and …, 2020 - Wiley Online Library
The human central nervous system (CNS) vasculature expresses a distinctive barrier
phenotype, the blood–brain barrier (BBB). As the BBB contributes to low efficiency in CNS …

Brain-on-a-chip: A history of development and future perspective

S Bang, S Jeong, N Choi, HN Kim - Biomicrofluidics, 2019 - pubs.aip.org
Since the advent of organ-on-a-chip, many researchers have tried to mimic the physiology of
human tissue on an engineered platform. In the case of brain tissue, structural connections …

Human mini-brain models

HY Tan, H Cho, LP Lee - Nature biomedical engineering, 2021 - nature.com
Engineered human mini-brains, made possible by knowledge from the convergence of
precision microengineering and cell biology, permit systematic studies of complex …

Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance

J Lim, H Ching, JK Yoon, NL Jeon, YT Kim - Nano Convergence, 2021 - Springer
Recent developments of organoids engineering and organ-on-a-chip microfluidic
technologies have enabled the recapitulation of the major functions and architectures of …

A 3D disease and regeneration model of peripheral nervous system–on–a–chip

S Hyung, SR Lee, J Kim, Y Kim, S Kim, HN Kim… - Science …, 2021 - science.org
Demyelinating diseases involve loss of myelin sheaths and eventually lead to neurological
problems. Unfortunately, the precise mechanisms remain unknown, and there are no …