The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are
involved in myriad cellular processes. Their distribution in various cellular compartments …

The glucose-regulated proteins (GRPs) are stress-inducible chaperones that mostly reside
in the endoplasmic reticulum or the mitochondria. Recent advances show that the GRPs …

The endoplasmic reticulum (ER) is a cellular organelle where secretory and membrane
proteins, as well as lipids, are synthesized and modified. When cells are subjected to ER …

Adaptive homeostasis is “the transient expansion or contraction of the homeostatic range for
any given physiological parameter in response to exposure to sub‐toxic, non‐damaging …

Sarcopenia is defined as the combined loss of skeletal muscle strength, function, and/or
mass with aging. This degenerative loss of muscle mass is associated with poor quality of …

Age-related loss of skeletal muscle mass and contractile dysfunction, or sarcopenia, reduces
independence and quality of life in the elderly and leads to increased risk of comorbidities …

The endoplasmic reticulum is a major compartment of protein biogenesis in the cell,
dedicated to production of secretory, membrane and organelle proteins. The secretome has …

The insulinlike growth factor-I (IGF-I) is an important factor which regulates a variety of
cellular responses in multiple biological systems. The IGF1 gene comprises a highly …

During tumor development and progression, intrinsic and extrinsic factors trigger
endoplasmic reticulum (ER) stress and the unfolded protein response, resulting in the …

As an endoplasmic reticulum heat shock protein (HSP) 90 paralogue, glycoprotein (gp) 96
possesses immunological properties by chaperoning antigenic peptides for activation of T …