The prevalence of neurodegenerative disease has increased significantly in recent years,
and with a rapidly aging global population, this trend is expected to continue. These …

Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …

Prion diseases are rapidly progressive, incurable neurodegenerative disorders caused by
misfolded, aggregated proteins known as prions, which are uniquely infectious. Remarkably …

An increasing number of studies continue to show that the amyloid β (Aβ) peptide adopts an
alternative conformation and acquires transmissibility; hence, it becomes a prion. Here, we …

Synucleinopathies are a group of neurodegenerative disorders caused by the misfolding
and self-templating of the protein α-synuclein, or the formation of α-synuclein prions. Each …

Prion diseases are neurodegenerative disorders characterized by the accumulation of
misfolded prion protein, spongiform changes in the brain, and brain inflammation as a result …

Bank voles are uniquely susceptible to a wide range of prion strains isolated from many
different species. To determine if this enhanced susceptibility to interspecies prion …

In prion diseases, the species barrier limits the transmission of prions from one species to
another. However, cross-species prion transmission is remarkably efficient in bank voles …

Several decades ago, a mysterious transmissible agent was found responsible for a group
of progressive and lethal encephalopathies affecting the nervous system of both animals …

Prions are the proteinaceous infectious agents responsible for the transmission of prion
diseases. The main or sole component of prions is the misfolded prion protein (PrPSc) …