Dental anomalies are caused by complex interactions between genetic, epigenetic and
environmental factors during the long process of dental development. This process is …

Hypohidrotic (anhidrotic) ectodermal dysplasia (HED) is a congenital syndrome
characterized by sparse hair, oligodontia, and reduced sweating. It is caused by mutations in …

Tooth agenesis or hypodontia, failure to develop all normally developing teeth, is one of the
most common developmental anomalies in man. Common forms, including third molar …

Background Orodental diseases include several clinically and genetically heterogeneous
disorders that can present in isolation or as part of a genetic syndrome. Due to the vast …

Oligodontia is defined as the congenital lack of six or more permanent teeth, excluding third
molars. Oligodontia as well as hypodontia (lack of one or more permanent teeth) are highly …

The genetic basis of the development and variation of adult form of vertebrates is not well
understood. To address this problem, we performed a mutant screen to identify genes …

The clinical importance of variations of tooth number, size and shape is seen in many dental
disciplines. Early diagnosis allows optimal patient management and treatment planning …

X-chromosome inactivation (XCI) provides a dosage compensation mechanism where, in
each female cell, one of the two X chromosomes is randomly silenced. However, some …

In humans, inherited variation in the number, size, and shape of teeth within the dentitions
are relatively common, while rarer defects of hard tissue formation, including amelogenesis …

The ectodysplasin (EDA) pathway, which is active during the development of ectodermal
organs, including teeth, hairs, feathers, and mammary glands, and which is crucial for fine …