Unraveling the dynamic mechanisms of natural killer cells in viral infections: insights and implications

A Letafati, OS Ardekani, M Naderisemiromi, M Norouzi… - Virology Journal, 2024 - Springer
Viruses pose a constant threat to human well-being, necessitating the immune system to
develop robust defenses. Natural killer (NK) cells, which play a crucial role in the immune …

Can natural killer cells be a principal player in anti-SARS-CoV-2 immunity?

F Ahmed, DH Jo, SH Lee - Frontiers in immunology, 2020 - frontiersin.org
The spread of the coronavirus disease 2019 (COVID-19) pandemic has led to disastrous
consequences, impacting social, economic, and medical systems, spanning both developed …

NK cells and monocytes modulate primary HTLV-1 infection

R Moles, S Sarkis, V Galli, M Omsland, M Artesi… - PLoS …, 2022 - journals.plos.org
We investigated the impact of monocytes, NK cells, and CD8+ T-cells in primary HTLV-1
infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type …

Novel insights into human T‐lymphotropic virus type‐1 (HTLV‐1) pathogenesis‐host interactions in the manifestation of HTLV‐1‐associated myelopathy/tropical …

S Ahmadi Ghezeldasht, A Mosavat… - Reviews in Medical …, 2024 - Wiley Online Library
Human T‐lymphotropic virus type‐1 (HTLV‐1) was the first discovered human oncogenic
retrovirus, the etiological agent of two serious diseases have been identified as adult T‐cell …

Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson's disease patients in a two-year follow-up: A case control study

DD Álvarez-Luquín, A Guevara-Salinas… - Journal of Translational …, 2021 - Springer
Background Neuroinflammation has been proved to play a role in dopaminergic neuronal
death in Parkinson's disease (PD). This link highlights the relevance of the immune …

Comprehensive Insight into the Functional Roles of NK and NKT Cells in HTLV-1-Associated Diseases and Asymptomatic Carriers

M Mahdifar, R Boostani, GP Taylor, SA Rezaee… - Molecular …, 2024 - Springer
The effector mechanisms exerted by the innate and adaptive immune response play a
critical role against viral infections. Among these mechanisms, natural killer cell (NKC)-and …

Complete Rescue of HTLV-1p12KO Infectivity by Depletion of Monocytes Together with NK and CD8+ T Cells

A Gutowska, S Sarkis, MA Rahman, KC Goldfarbmuren… - Pathogens, 2024 - mdpi.com
The transient depletion of monocytes alone prior to exposure of macaques to HTLV-1
enhances both HTLV-1WT (wild type) and HTLV-1p12KO (Orf-1 knockout) infectivity, but …

Hijacking Host Immunity by the Human T-Cell Leukemia Virus Type-1: Implications for Therapeutic and Preventive Vaccines

CA Pise-Masison, G Franchini - Viruses, 2022 - mdpi.com
Human T-cell Leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma
(ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and other …

Functional capacity of natural killer cells in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients

GAN Queiroz, REM Mascarenhas, V Vieillard… - BMC infectious …, 2019 - Springer
Background Natural killer (NK) cells are part of the innate immune system and provide
surveillance against viruses and cancers. The ability of NK cells to kill virus-infected cells …

Immunopathogenesis and cellular interactions in human T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis

S Aghajanian, M Teymoori-Rad, G Molaverdi… - Frontiers in …, 2020 - frontiersin.org
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a
neuropathological disorder in 1–3% of individuals infected with Human T-lymphotropic virus …