Ontogeny of the circadian system: a multiscale process throughout development

M Comas, DDP Tonelli, L Berdondini, M Astiz - Trends in Neurosciences, 2024 - cell.com
The 24 h (circadian) timing system develops in mammals during the perinatal period. It
carries out the essential task of anticipating daily recurring environmental changes to identify …

Roles of retrovirus-derived PEG10 and PEG11/RTL1 in mammalian development and evolution and their involvement in human disease

H Shiura, M Kitazawa, F Ishino… - Frontiers in Cell and …, 2023 - frontiersin.org
PEG10 and PEG11/RTL1 are paternally expressed, imprinted genes that play essential
roles in the current eutherian developmental system and are therefore associated with …

Activity-dependent modulation of synapse-regulating genes in astrocytes

I Farhy-Tselnicker, MM Boisvert, H Liu, C Dowling… - Elife, 2021 - elifesciences.org
Astrocytes regulate the formation and function of neuronal synapses via multiple signals;
however, what controls regional and temporal expression of these signals during …

Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice

MY Chou, X Cao, KC Hou, MH Tsai, CY Lee… - Communications …, 2023 - nature.com
Genomic imprinting predominantly occurs in the placenta and brain. Few imprinted
microRNAs have been identified in the brain, and their functional roles in the brain are not …

Variable allelic expression of imprinted genes at the Peg13, Trappc9, Ago2 cluster in single neural cells

M Claxton, M Pulix, MKY Seah, R Bernardo… - Frontiers in Cell and …, 2022 - frontiersin.org
Genomic imprinting is an epigenetic process through which genes are expressed in a parent-
of-origin specific manner resulting in mono-allelic or strongly biased expression of one …

[HTML][HTML] Influences of genomic imprinting on brain function and behavior

O Ho-Shing, C Dulac - Current opinion in behavioral sciences, 2019 - Elsevier
Highlights•Imprinted effects in the brain range from monoallelic to parentally-biased
expression.•Imprinted expression is highly specific to brain region, cell type, and …

Epigenetic and cellular diversity in the brain through allele-specific effects

WC Huang, K Bennett, C Gregg - Trends in neurosciences, 2018 - cell.com
The benefits of diploidy are considered to involve masking partially recessive mutations and
increasing genetic diversity. Here, we review new studies showing evidence for diverse …

RTL1/PEG11 imprinted in human and mouse brain mediates anxiety-like and social behaviors and regulates neuronal excitability in the locus coeruleus

MY Chou, MC Hu, PY Chen, CL Hsu… - Human Molecular …, 2022 - academic.oup.com
Abstract RTL1/PEG11, which has been associated with anxiety disorders, is a
retrotransposon-derived imprinted gene in the placenta. However, imprinting patterns and …

Modeling allele-specific expression at the gene and SNP levels simultaneously by a Bayesian logistic mixed regression model

J Xie, T Ji, MAR Ferreira, Y Li, BN Patel, RM Rivera - BMC bioinformatics, 2019 - Springer
Background High-throughput sequencing experiments, which can determine allele origins,
have been used to assess genome-wide allele-specific expression. Despite the amount of …

Mouse hybrid genome mediates diverse brain phenotypes with the specificity of reciprocal crosses

MY Chou, D Appan, KW Chang, CH Chou… - The FASEB …, 2022 - Wiley Online Library
Hybrid species have more genetic diversity than their parents. However, the impact of the
hybrid genome of reciprocal crosses on brain function remains largely unknown. We …