The uroepithelium sits at the interface between the urinary space and underlying tissues,
where it forms a high-resistance barrier to ion, solute, and water flux, as well as pathogens …

There are a number of conditions of the bladder that can lead to loss of function. Many of
these require reconstructive procedures. However, current techniques may lead to a number …

The urothelium is a stratified epithelium composed of basal cells, one or more layers of
intermediate cells, and an upper layer of differentiated umbrella cells. Most bladder cancers …

Background Autologous urothelial cells are often obtained via bladder biopsy to generate
the bio-engineered urethra or bladder, while urine-derived stem cells (USC) can be …

Approximately 50% of patients with muscle-invasive bladder cancer (MIBC) develop
metastatic disease, which is almost invariably lethal. However, our understanding of …

Background Primary culture and animal and cell-line models of prostate and bladder
development have limitations in describing human biology, and novel strategies that …

Urinary bladder is a dynamic organ performing complex physiological activities. Together
with ureters and urethra, it forms the lower urinary tract that facilitates urine collection, low …

We previously found loss of forkhead box A1 (FOXA1) expression to be associated with
aggressive urothelial carcinoma of the bladder, as well as increased tumor proliferation and …

In order to reconstruct injured urinary tract tissues, biodegradable scaffolds with autologous
seeded cells are explored in this work. However, when cells are obtained via biopsy from …

Skin and bladder epithelia form effective permeability barriers through the activation of
distinct differentiation gene programs. Using a genome‐wide gene‐expression study, we …