Effects of SGLT2 inhibitors on kidney and cardiovascular function

V Vallon, S Verma - Annual review of physiology, 2021 - annualreviews.org
SGLT2 inhibitors are antihyperglycemic drugs that protect kidneys and the heart of patients
with or without type 2 diabetes and preserved or reduced kidney function from failing. The …

The impact of SGLT2 inhibition on imaging markers of cardiac function: A systematic review and meta-analysis

P Theofilis, AS Antonopoulos, T Katsimichas… - Pharmacological …, 2022 - Elsevier
Objectives The use of sodium-glucose cotransporter-2 inhibitors (SGLT2-Is) has resulted in
significant benefits in patients with heart failure irrespective of left ventricular ejection fraction …

Dipeptidyl peptidase‐4 inhibitors, glucagon‐like peptide 1 receptor agonists and sodium‐glucose co‐transporter‐2 inhibitors for people with cardiovascular disease: a …

Y Takaoka, T Suzuki, D Yoneoka… - Cochrane Database …, 2021 - cochranelibrary.com
Background Cardiovascular disease (CVD) is a leading cause of death globally. Recently,
dipeptidyl peptidase‐4 inhibitors (DPP4i), glucagon‐like peptide‐1 receptor agonists (GLP …

Empagliflozin and left ventricular remodeling in people without diabetes: primary results of the EMPA-HEART 2 CardioLink-7 randomized clinical trial

KA Connelly, CD Mazer, P Puar, H Teoh, CH Wang… - Circulation, 2023 - Am Heart Assoc
Background: Sodium-glucose cotransporter 2 inhibitors have been demonstrated to promote
reverse cardiac remodeling in people with diabetes or heart failure. Although it has been …

Empagliflozin improves circulating vascular regenerative cell content in people without diabetes with risk factors for adverse cardiac remodeling

E Bakbak, S Verma, A Krishnaraj… - American Journal …, 2023 - journals.physiology.org
Sodium glucose-cotransporter 2 (SGLT2) inhibitors have been reported to reduce
cardiovascular events and heart failure in people with and without diabetes. These …

Impact of empagliflozin on right ventricular parameters and function among patients with type 2 diabetes

B Sarak, S Verma, C David Mazer, H Teoh… - Cardiovascular …, 2021 - Springer
Background Sodium-glucose cotransporter 2 (SGLT2) inhibition reduces cardiovascular
events in type 2 diabetes (T2DM) and is associated with a reduction in left ventricular (LV) …

Anti-Inflammation and Anti-Oxidation: The Key to Unlocking the Cardiovascular Potential of SGLT2 Inhibitors and GLP1 Receptor Agonists

VA Myasoedova, M Bozzi, V Valerio, D Moschetta… - Antioxidants, 2023 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a prevalent and complex metabolic disorder associated
with various complications, including cardiovascular diseases. Sodium-glucose co …

Empagliflozin and left ventricular diastolic function following an acute coronary syndrome in patients with type 2 diabetes

NSR Lan, BB Yeap, PG Fegan, G Green… - The international journal …, 2021 - Springer
Sodium-glucose cotransporter 2 inhibitors can improve heart failure outcomes, however, the
effects on left ventricular (LV) function remain unclear. This prospective observational study …

Sizing SGLT2 Inhibitors Up: From a Molecular to a Morpho-Functional Point of View

S Prosperi, A D'Amato, P Severino, V Myftari… - International Journal of …, 2023 - mdpi.com
Sodium–glucose cotransporter 2 inhibitors (SGLT2i), or gliflozins, have recently been shown
to reduce cardiovascular death and hospitalization in patients with heart failure …

Sodium-glucose cotransporter type 2 (SGLT-2) inhibitors and ketogenesis: the good and the bad

P Ekanayake, C Hupfeld, S Mudaliar - Current Diabetes Reports, 2020 - Springer
Abstract Purpose of Review The micro/macrovascular complications of diabetes cause
considerable morbidity and premature mortality. The SGLT2 inhibitors are the first diabetes …