The rapid development of angiogenic growth factor therapy for patients with advanced
ischemic heart disease over the last 5 years offers hope of a new treatment strategy based …

Despite considerable progress in the management of ischaemic cardiovascular disease
during the past three decades, there remains a significant population of patients who are not …

Objectives: The aim of this study was to examine the effects of sarcoplasmic reticulum Ca2+
ATPase (SERCA2a) gene transfer in a swine heart failure (HF) model. Background …

Objectives: This study was undertaken to optimize echocardiographic parameters for
successful gene delivery to the heart and to extend the method from adenoviral to plasmid …

Abnormal excitation–contraction coupling is a key pathophysiologic component of heart
failure (HF), and at a molecular level reduced expression of the sarcoplasmic reticulum (SR) …

Modern treatment of cardiac arrhythmias is limited to pharmacotherapy, radiofrequency
ablation, or implantable devices. Antiarrhythmic medications suppress arrhythmias, but their …

To evaluate the concept that localized delivery of angiogenic factors via virus-mediated
gene transfer may be useful in the treatment of ischemic disorders, the replication-deficient …

Publisher Summary The high efficiency of gene transfer mediated by recombinant
Adenovirus (Ad) has prompted the construction of dozens of first-generation Ad vectors for …

Background Based on assessment of mRNA expression, the lung is a major site of
expression of the vascular endothelial growth factor (VEGF) gene, largely from type II …

Background—Safe and effective myocardial gene transfer remains elusive. Heterogeneous
ventricular gene delivery has been achieved in small mammals but generally with methods …