Cells of origin of lung cancers: lessons from mouse studies
As one of the most common forms of cancer, lung cancers present as a collection of different
histological subtypes. These subtypes are characterized by distinct sets of driver mutations …
histological subtypes. These subtypes are characterized by distinct sets of driver mutations …
Recent advances in preclinical models for lung squamous cell carcinoma
Lung squamous cell carcinoma (LUSC) represents a major subtype of non-small cell lung
cancer with limited treatment options. Previous studies have elucidated the complex genetic …
cancer with limited treatment options. Previous studies have elucidated the complex genetic …
[HTML][HTML] LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network
Y Zhang, YX Huang, DL Wang, B Yang, HY Yan… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: The forkhead box A1 (FOXA1) is a crucial transcription factor in initiation and
development of breast, lung and prostate cancer. Previous studies about the FOXA1 …
development of breast, lung and prostate cancer. Previous studies about the FOXA1 …
Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer
PC Ghazi, KT O'Toole, SS Boggaram, MT Scherzer… - Elife, 2024 - elifesciences.org
Mutational activation of KRAS occurs commonly in lung carcinogenesis and, with the recent
US Food and Drug Administration approval of covalent inhibitors of KRAS G12C such as …
US Food and Drug Administration approval of covalent inhibitors of KRAS G12C such as …
Transcriptional control of lung alveolar type 1 cell development and maintenance by NK homeobox 2-1
DR Little, KN Gerner-Mauro, P Flodby… - Proceedings of the …, 2019 - National Acad Sciences
The extraordinarily thin alveolar type 1 (AT1) cell constitutes nearly the entire gas exchange
surface and allows passive diffusion of oxygen into the blood stream. Despite such an …
surface and allows passive diffusion of oxygen into the blood stream. Despite such an …
Counteracting lineage-specific transcription factor network finely tunes lung adeno-to-squamous transdifferentiation through remodeling tumor immune …
Human lung adenosquamous cell carcinoma (LUAS), containing both adenomatous and
squamous pathologies, harbors strong plasticity and is significantly associated with poor …
squamous pathologies, harbors strong plasticity and is significantly associated with poor …
The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2
Age is a major risk factor for severe coronavirus disease-2019 (COVID-19). Here, we
interrogate the transcriptional features and cellular landscape of the aging human lung. By …
interrogate the transcriptional features and cellular landscape of the aging human lung. By …
Epigenetic reprogramming of a distal developmental enhancer cluster drives SOX2 overexpression in breast and lung adenocarcinoma
Enhancer reprogramming has been proposed as a key source of transcriptional
dysregulation during tumorigenesis, but the molecular mechanisms underlying this process …
dysregulation during tumorigenesis, but the molecular mechanisms underlying this process …
Spatial Transcriptomics of Intraductal papillary mucinous neoplasms of the Pancreas identifies Nkx6-2 as a driver of gastric differentiation and indolent biological …
M Sans, Y Makino, J Min, KI Rajapakshe… - Cancer discovery, 2023 - AACR
Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are bona fide precursor
lesions of pancreatic ductal adenocarcinoma (PDAC). The most common subtype of IPMNs …
lesions of pancreatic ductal adenocarcinoma (PDAC). The most common subtype of IPMNs …
FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma
J Li, Y Zhang, L Wang, M Li, J Yang, P Chen… - Cell Death & …, 2022 - nature.com
Lung cancer remains one of the most common malignancies and the leading cause of
cancer-related death worldwide. Forkhead box protein A1 (FOXA1) is a pioneer factor …
cancer-related death worldwide. Forkhead box protein A1 (FOXA1) is a pioneer factor …