MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene
expression by binding to specific mRNA targets and promoting their degradation and/or …

Although the signaling pathways involved in normal liver regeneration have been well
characterized, less has been done for livers affected by chronic tissue damage. These …

Identifying new pathways that regulate mammalian regeneration is challenging due to the
paucity of in vivo screening approaches. We employed pooled CRISPR knockout and …

The adult liver has an exceptional ability to regenerate, but how it maintains its specialized
functions during regeneration is unclear. Here, we used partial hepatectomy (PHx) in …

Non-coding RNAs (ncRNAs) have diverse functions in health and pathology in many
tissues, including the liver. This review highlights important microRNAs (miRs), long non …

The principle of hydrodynamic delivery was initially used to develop a method for the
delivery of plasmids into mouse hepatocytes through tail vein injection and has been …

microRNAs (miRNAs) are critically involved in liver regeneration (LR). miR-125a-5p (miR-
125a) is a tumor-suppressing miRNA, but its role in LR has not been studied. Our previous …

The regenerative capabilities of the liver represent a paradigm for understanding tissue
repair in solid organs. Regeneration after partial hepatectomy in rodent models is well …

Background & Aims: Reactive oxygen species (ROS) act as modulators triggering cellular
dysfunctions and organ damage including liver fibrosis in which hepatic stellate cell (HSC) …

Introduction and objectives N-acetyl-p-aminophenol (APAP)-induced liver injury is a major
clinical challenge worldwide. The present study investigated the molecular role of microRNA …