Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular
processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal …

Cellular senescence is a state of irreversible cell cycle arrest associated with ageing.
Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular …

Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …

Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are
degraded intracellularly. Autophagy has also emerged as a major regulator of cardiac …

Since the discovery that rapamycin, a small molecule inhibitor of the protein kinase mTOR
(mechanistic target of rapamycin), can extend the lifespan of model organisms including …

Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …

The aging population is increasing in developed countries. Because the incidence of
cardiac disease increases dramatically with age, it is important to understand the molecular …

Background—Mitochondrial autophagy is an important mediator of mitochondrial quality
control in cardiomyocytes. The occurrence of mitochondrial autophagy and its significance …

Accumulating evidence reveals that metabolic and cell survival pathways are closely
related, sharing common signaling molecules. Hexokinase catalyzes the phosphorylation of …