Protozoan parasites have developed elaborate motility systems that facilitate infection and
dissemination. For example, amoebae use actin-rich membrane extensions called …

The malaria parasite life cycle alternates between two hosts: a vertebrate and the female
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …

Malaria is caused by unicellular Plasmodium parasites. Plasmodium relies on diverse
microtubule cytoskeletal structures for its reproduction, multiplication, and dissemination …

The myosin holoenzyme is a multimeric protein complex consisting of heavy chains and light
chains. Myosin light chains are calmodulin family members which are crucially involved in …

Myosins are among the most fascinating enzymes in biology. As extremely allosteric
chemomechanical molecular machines, myosins are involved in myriad pivotal cellular …

Many members of the phylum of Apicomplexa have adopted an obligate intracellular life
style and critically depend on active invasion and egress from the infected cells to complete …

During each cycle of asexual endomitotic division in erythrocytes, the malaria parasite
makes a fundamental and crucial decision: to continue to invade and proliferate or to …

Morphogenesis of many protozoans depends on a polarized establishment of cortical
cytoskeleton containing the subpellicular microtubules (SPMTs), which are apically …

The phylum Apicomplexa has been defined by the presence of the apical complex, a
structure composed of secretory organelles and specific cytoskeletal elements. A …

Ookinete gliding motility is essential for penetration of the mosquito midgut wall and
transmission of malaria parasites. Cyclic guanosine monophosphate (cGMP) signaling has …