Sugars and Polyols of Natural Origin as Carriers for Solubility and Dissolution Enhancement

MS Poka, M Milne, A Wessels, M Aucamp - Pharmaceutics, 2023 - mdpi.com
Crystalline carriers such as dextrose, sucrose, galactose, mannitol, sorbitol, and isomalt
have been reported to increase the solubility, and dissolution rates of poorly soluble drugs …

Solid dispersion technology, a contemporary overview on a well established technique

MA Younis - Universal Journal of Pharmaceutical Research, 2017 - ujpronline.com
Solubility is a significant physicochemical parameter that affects the absorption,
bioavailability and therapeutic effectiveness of any drug. Formulation development would …

Brain-targeted delivery of Valsartan using solid lipid nanoparticles labeled with Rhodamine B; a promising technique for mitigating the negative effects of stroke

SA Sabry, AM Abd El Razek, M Nabil, SM Khedr… - Drug Delivery, 2023 - Taylor & Francis
The brain is a vital organ that is protected from the general circulation and is distinguished
by the presence of a relatively impermeable blood brain barrier (BBB). Blood brain barrier …

Development and characterization of glimepiride novel solid nanodispersion for improving its oral bioavailability

M Qushawy, A Nasr, S Swidan, Y Mortagi - Scientia Pharmaceutica, 2020 - mdpi.com
Glimepiride is an antidiabetic drug which is one of the third generation sulfonylureas. It
belongs to class II, according to the BCS (Biopharmaceutical Classification System), which is …

Design and development of solid dispersion of valsartan by a lyophilization technique: A 32 factorial design approach

NR Shirsath, AK Goswami - Micro and Nanosystems, 2021 - ingentaconnect.com
Background: Valsartan is a poorly water-soluble drug having limited oral bioavailability. Its
absorption and onset of action mostly depend on its solubility. Therefore, its solubility needs …

Formulation and enhancement of dissolution rate of poorly aqueous soluble drug Aceclofenac by solid dispersion method: In vitro study

S Neupane, C Thapa - African Journal of Pharmacy and …, 2020 - academicjournals.org
Solid dispersion technique was successfully used to enhance the dissolution of poorly
aqueous soluble drugs aceclofenac. Four carriers Hydroxyl propyl methylcellulose (HPMC) …

Development and Characterisation of Polymeric Solid Dispersion Systems of Hesperidin Obtained by the Method of Centrifugal Fibre Formation

V Bessarabov, V Lisovyi, V Lyzhniuk, V Kostiuk… - Available at SSRN … - papers.ssrn.com
The flavonoid hesperidin is a crucial biologically active substance of great interest due to its
polypharmacological properties and high safety profile. However, the wide use of this …

Development and Characterization of Glimepiride Novel Solid Nanodispersion for Improving Its Oral Bioavailability

S Swidan, M Qushawy, A Nasr, Y Mortagi - 2020 - buescholar.bue.edu.eg
Glimepiride is an antidiabetic drug which is one of the third generation sulfonylureas. It
belongs to class II, according to the BCS (Biopharmaceutical Classification System), which is …

PERBEDAAN PROFIL DISOLUSI KURKUMIN DALAM SISTEM DISPERSI PADAT EKSTRAK KUNYIT DENGAN VARIASI RASIO POLOXAMER 407/MANITOL

AP Widiastuti - library.usd.ac.id
Kurkumin merupakan salah satu senyawa utama yang berasal dari ekstrak kunyit (Curcuma
longa L.) yang memiliki banyak manfaat dalam industri makanan dan memiliki aktifitas …