The implications of IDH mutations for cancer development and therapy
CJ Pirozzi, H Yan - Nature reviews Clinical oncology, 2021 - nature.com
Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …
Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
IC Hvinden, T Cadoux-Hudson, CJ Schofield… - Cell Reports …, 2021 - cell.com
The most frequently mutated metabolic genes in human cancer are those encoding the
enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been …
enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been …
Dysregulated lipid synthesis by oncogenic IDH1 mutation is a targetable synthetic lethal vulnerability
D Thomas, M Wu, Y Nakauchi, M Zheng… - Cancer discovery, 2023 - AACR
Abstract Isocitrate dehydrogenase 1 and 2 (IDH) are mutated in multiple cancers and drive
production of (R)-2-hydroxyglutarate (2HG). We identified a lipid synthesis enzyme [acetyl …
production of (R)-2-hydroxyglutarate (2HG). We identified a lipid synthesis enzyme [acetyl …
Integration of lipidomics and transcriptomics reveals reprogramming of the lipid metabolism and composition in clear cell renal cell carcinoma
G Lucarelli, M Ferro, D Loizzo, C Bianchi… - Metabolites, 2020 - mdpi.com
Clear cell renal cell carcinoma (ccRCC) is fundamentally a metabolic disease. Given the
importance of lipids in many cellular processes, in this study we delineated a lipidomic …
importance of lipids in many cellular processes, in this study we delineated a lipidomic …
Metabolic Rewiring in Glioblastoma Cancer: EGFR, IDH and Beyond
Glioblastoma multiforme (GBM), a highly invasive and incurable tumor, is the humans'
foremost, commonest, and deadliest brain cancer. As in other cancers, distinct combinations …
foremost, commonest, and deadliest brain cancer. As in other cancers, distinct combinations …
Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia
The interaction of germline variation and somatic cancer driver mutations is under-
investigated. Here we describe the genomic mitochondrial landscape in adult acute myeloid …
investigated. Here we describe the genomic mitochondrial landscape in adult acute myeloid …
[HTML][HTML] Metabolic remodeling in astrocytes: Paving the path to brain tumor development
M Jaraíz-Rodríguez, L Del Prado, E Balsa - Neurobiology of Disease, 2023 - Elsevier
The brain is a highly metabolic organ, composed of multiple cell classes, that controls crucial
functions of the body. Although neurons have traditionally been the main protagonist …
functions of the body. Although neurons have traditionally been the main protagonist …
Transcriptome analysis of porcine granulosa cells in healthy and atretic follicles: role of steroidogenesis and oxidative stress
L Meng, Z Wu, K Zhao, J Tao, T Chit, S Zhang… - Antioxidants, 2020 - mdpi.com
One of the main causes of female infertility is a deregulated antral follicular atresia, a
process of which the underlying molecular mechanisms are largely unknown. Our objective …
process of which the underlying molecular mechanisms are largely unknown. Our objective …
Energy Metabolism in IDH1 Wild-Type and IDH1-Mutated Glioblastoma Stem Cells: A Novel Target for Therapy?
CJF van Noorden, VVV Hira, AJ van Dijck, M Novak… - Cells, 2021 - mdpi.com
Cancer is a redox disease. Low levels of reactive oxygen species (ROS) are beneficial for
cells and have anti-cancer effects. ROS are produced in the mitochondria during ATP …
cells and have anti-cancer effects. ROS are produced in the mitochondria during ATP …