Phospholipase A2 enzymes

I Kudo, M Murakami - Prostaglandins & other lipid mediators, 2002 - Elsevier
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …

Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke

C Rink, S Khanna - Antioxidants & redox signaling, 2011 - liebertpub.com
The significance of the hypoxia component of stroke injury is highlighted by hypermetabolic
brain tissue enriched with arachidonic acid (AA), a 22: 6n-3 polyunsaturated fatty acid. In an …

Global gene profiling in human endometrium during the window of implantation

LC Kao, S Tulac, S Lobo, B Imani, JP Yang… - …, 2002 - academic.oup.com
Implantation in humans is a complex process that is temporally and spatially restricted. Over
the past decade, using a one-by-one approach, several genes and gene products that may …

Cytidine 5′-diphosphocholine (CDP-choline) in stroke and other CNS disorders

RM Adibhatla, JF Hatcher - Neurochemical research, 2005 - Springer
Brain phosphatidylcholine (PC) levels are regulated by a balance between synthesis and
hydrolysis. Pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and …

Palm oil–derived natural vitamin E α-tocotrienol in brain health and disease

CK Sen, C Rink, S Khanna - Journal of the American College of …, 2010 - Taylor & Francis
A growing body of research supports that members of the vitamin E family are not redundant
with respect to their biological function. Palm oil derived from Elaeis guineensis represents …

Phospholipase A2, Hydroxyl Radicals, and Lipid Peroxidation in Transient Cerebral Ischemia

RM Adibhatla, JF Hatcher… - Antioxidants and redox …, 2003 - liebertpub.com
Phospholipid degradation is an important promoter of neuronal death after transient cerebral
ischemia. Phospholipid hydrolysis by phospholipase A2 (PLA2) after transient cerebral …

The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases

GY Sun, LA Horrocks, AA Farooqui - Journal of neurochemistry, 2007 - Wiley Online Library
Reactive oxygen species (ROS) are produced in mammalian cells through enzymic and non‐
enzymic mechanisms. Although some ROS production pathways are needed for specific …

Regulation of arachidonic acid availability for eicosanoid production

CC Leslie - Biochemistry and cell biology, 2004 - cdnsciencepub.com
Les cellules de mammifères ont acquis des voies spécifiques pour l'incorporation, la
redistribution et la libération de l'acide arachidonique. Les voies de l'acyltransférase et de la …

Citicoline decreases phospholipase A2 stimulation and hydroxyl radical generation in transient cerebral ischemia

RM Adibhatla, JF Hatcher - Journal of neuroscience research, 2003 - Wiley Online Library
Neuroprotection by citicoline (CDP‐choline) in transient cerebral ischemia has been
demonstrated previously. Citicoline has undergone several Phase III clinical trials for stroke …

Proinflammatory cytokine IL-1β stimulates IL-8 synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway, contributing to angiogenesis

GY Kim, JW Lee, HC Ryu, JD Wei… - The Journal of …, 2010 - journals.aai.org
Recent studies have suggested that mast cells have critical roles in angiogenesis. However,
the detailed mechanism by which mast cells contribute to angiogenesis is not yet clearly …