Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …

Breast Cancer Type 1 Susceptibility Protein (BRCA1) is a tumor-suppressor protein that
regulates various cellular pathways, including those that are essential for preserving …

RNF168 plays a central role in the DNA damage response (DDR) by ubiquitylating histone
H2A at K13 and K15. These modifications direct BRCA1-BARD1 and 53BP1 foci formation …

Chromatin association of the BRCA1–BARD1 heterodimer is critical to promote homologous
recombination repair of DNA double-strand breaks (DSBs) in S/G2. How the BRCA1 …

A dynamic array of histone post-translational modifications (PTMs) regulate diverse cellular
processes in the eukaryotic chromatin. Among them, histone ubiquitination is particularly …

Epigenetic inheritance of silent chromatin domains is fundamental to cellular memory during
embryogenesis, but it must overcome the dilution of repressive histone modifications during …

RAD18 is an E3 ubiquitin ligase that prevents replication fork collapse by promoting DNA
translesion synthesis and template switching. Besides this classical role, RAD18 has been …

The tumor suppressor breast cancer 1 (BRCA1) complexed with BRCA1-associated RING
domain 1 (BARD1), a RING-type E3 ligase, facilitates the attachment of ubiquitin onto the …

Summary “Revolutionizing Drug Delivery Through Computational Design: Nanotechnology
and Personalized Therapeutics” explores the transformative potential of computational …

Previously, we reconstituted a minimal functional kinetochore from recombinant S.
cerevisiae proteins that was capable of transmitting force from dynamic microtubules to …