Glaucoma clinical research: Trends in treatment strategies and drug development

L Storgaard, TL Tran, JC Freiberg, AS Hauser… - Frontiers in …, 2021 - frontiersin.org
Purpose: To investigate the trends and progresses in glaucoma research by searching two
major clinical trial registries; clinicaltrials. gov, and Australianclinicaltrials. gov. au. Methods …

Topical preservative-free ophthalmic treatments: an unmet clinical need

M Figus, L Agnifili, M Lanzini, L Brescia… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: The main role of preservatives in eyedrops is to ensure sterility and
microbiological integrity of the drug, and to facilitate the penetration of active compounds …

[HTML][HTML] Inflammatory model in patients with primary open angle glaucoma and diabetes

A Pantalon, O Obadă, D Constantinescu… - International Journal …, 2019 - ncbi.nlm.nih.gov
AIM To assess the inflammatory cytokines expression in aqueous humor in diabetic primary
open angle glaucoma (POAG) patients. METHODS A cross-sectional study on 87 eyes …

Current progress in preservative-free topical ophthalmic formulations

N Vasdev, N Chaudhari, S Polaka, K Rajpoot… - Journal of Drug Delivery …, 2023 - Elsevier
Ophthalmic formulations have enormous applications in treating several ocular disorders.
Principally, the ocular formulations must be sterile. Hence, preservatives are conventionally …

Tear cytokine profile of glaucoma patients treated with preservative-free or preserved latanoprost

JM Martinez-de-la-Casa, F Perez-Bartolome… - The ocular …, 2017 - Elsevier
Purpose To determine variations in cytokine levels of glaucoma patients treated either with
preservative-free latanoprost or preserved latanoprost, relative to healthy individuals …

In vitro and in vivo evaluation of brimonidine loaded silica nanoparticles-laden silicone contact lenses to manage glaucoma

Y Xu, H Li - Journal of Biomaterials Applications, 2022 - journals.sagepub.com
Glaucoma is treated by frequent instillation of 0.2% w/v brimonidine tartrate eye drop
solution, which showed poor ocular bioavailability of 1–3%. Medicated contact lenses can …

Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa

A Trzeciecka, JJ Paterno, E Toropainen… - European Journal of …, 2016 - Elsevier
Success of the long-term glaucoma therapy and preservation of the visual function strongly
depend on patients' compliance which may be affected by the inconvenience of treatment …

Open-angle glaucoma: drug development pipeline during the last 20 years (1995-2015)

A Vicente, S Prud'homme, J Ferreira… - Ophthalmic …, 2017 - karger.com
Objectives: To analyse drug development for open-angle glaucoma during the last 20 years.
Methods: Research was performed by referring to clinical trials registered at the International …

Real-Life Study on the Efficacy and Tolerance of a Preservative-Free Surfactant-Free Latanoprost Eye Drop in Patients with Glaucoma

L Chauchat, C Guerin, H Rebika, M Sahyoun… - Ophthalmology and …, 2024 - Springer
Introduction The purpose of this study is to assess the real-life efficacy and tolerance of a
new preservative-free, surfactant-free latanoprost (PFSF-LAT) formulation. Methods …

Allergic reactions to atropine eye drops for retardation of progressive myopia in children

M Kothari, R Jain, N Khadse, V Rathod… - Indian journal of …, 2018 - journals.lww.com
Purpose: To report clinical manifestations of ocular allergy to atropine eye drops used for
retardation of progressive myopia in children. Methods: Myopic children, who developed …