Bone marrow transplantation is regarded as the most effective immunotherapy for
hematologic cancer, but it generally faces difficulties in matching. Aberrant expression of …

Triple negative breast cancer (TNBC) is a highly aggressive breast cancer subtype
characterized by the lack in the expression of estrogen and progesterone receptors, and …

Breast cancer (BC) is one of the main types of cancer that endangers women's lives. The
characteristics of triple-negative breast cancer (TNBC) include a high rate of recurrence and …

Abstract Histone deacetylase 6 (HDAC6) contributes to cancer metastasis in several
cancers, including triple-negative breast cancer (TNBC)—the most lethal form that lacks …

HDAC inhibitors are an attractive class of cytotoxic agents for the design of hybrid
molecules. Several HDAC hybrids have emerged over the years, but none combines HDAC …

Ferroptosis and apoptosis are key cell‐death pathways implicated in several human
diseases including cancer. Ferroptosis is driven by iron‐dependent lipid peroxidation and …

Breast cancer remains one of the leading causes of cancer-related deaths globally and the
most prominent among females, yet with limited effective therapeutic options. Most of the …

Since Otto Warburg's first report on the increased uptake of glucose and lactate release by
cancer cells, dysregulated metabolism has been acknowledged as a hallmark of cancer that …

Modulation of estrogen receptor (ER) and progesterone receptor (PR) expression, as well as
their emerging functional crosstalk, remains a potential approach for enhancing the …

Simple Summary This review aims to analyze the clinical drawbacks faced by PKC inhibitors
and uncovering aspects that might potentially interfere with the clinical outcome of …