Cracking the code: reprogramming the genetic script in prokaryotes and eukaryotes to harness the power of noncanonical amino acids

C Jann, S Giofré, R Bhattacharjee, EA Lemke - Chemical Reviews, 2024 - ACS Publications
Over 500 natural and synthetic amino acids have been genetically encoded in the last two
decades. Incorporating these noncanonical amino acids into proteins enables many …

Chemical and Biological Strategies for Profiling Protein‐Protein Interactions in Living Cells

YY Wang, W Li, BC Ye, XB Bi - Chemistry–An Asian Journal, 2023 - Wiley Online Library
Protein‐protein interactions (PPIs) play critical roles in almost all cellular signal transduction
events. Characterization of PPIs without interfering with the functions of intact cells is very …

Construction and Catalytic Study of Affinity Peptide Orientation and Light Crosslinking Immobilized Sucrose Isomerase

N Shi, M Zheng, X Wu, N Chen, L Jiang… - Journal of Agricultural …, 2023 - ACS Publications
A novel affinity peptide orientation and light-controlled covalent immobilized method was
developed. Sucrose isomerase (SI) was selected as the model enzyme. Molecular …

Epitope-directed antibody selection by site-specific photocrosslinking

L Chen, C Zhu, H Guo, R Li, L Zhang, Z Xing… - Science …, 2020 - science.org
Currently, there are no methods available offering solutions to select and identify antibodies
binding to a specific conformational epitope of an antigen. Here, we developed a method to …

Non‐canonical Amino Acid Substrates of E. coli Aminoacyl‐tRNA Synthetases

MCT Hartman - ChemBioChem, 2022 - Wiley Online Library
In this comprehensive review, I focus on the twenty E. coli aminoacyl‐tRNA synthetases and
their ability to charge non‐canonical amino acids (ncAAs) onto tRNAs. The promiscuity of …

Reading and Writing the Ubiquitin Code Using Genetic Code Expansion

RS Patel, NM Pannala, C Das - ChemBioChem, 2024 - Wiley Online Library
Deciphering ubiquitin proteoform signaling and its role in disease has been a long‐standing
challenge in the field. The effects of ubiquitin modifications, its relation to ubiquitin‐related …

One-pot, two-step synthesis of unnatural α-amino acids involving the exhaustive aerobic oxidation of 1, 2-diols

H Inada, K Furukawa, M Shibuya… - Chemical …, 2019 - pubs.rsc.org
Herein, we report the nor-AZADO-catalyzed exhaustive aerobic oxidations of 1, 2-diols to α-
keto acids. Combining oxidation with transamination using DL-2-phenylglycine led to the …

Deciphering the conformational landscape of few selected aromatic noncoded amino acids (NCAAs) for applications in rational design of peptide therapeutics

LM Behera, M Ghosh, S Rana - Amino Acids, 2022 - Springer
Amino acids are the essential building blocks of both synthetic and natural peptides, which
are crucial for biological functions and also important as biological probes for mapping the …

[PDF][PDF] AN ASIAN JOURNAL

D Wang, X Wan, Y Zhou, J Liu, J Cai, GJ Deng - researchgate.net
Protein-protein interactions (PPIs) play critical roles in almost all cellular signal transduction
events. Characterization of PPIs without interfering with the functions of intact cells is very …