HIV-associated neurocognitive disorder (HAND) affects approximately half of HIV-infected
patients. Loss of synaptic connections is a hallmark of many neurocognitive disorders …

Seizures are common in patients with glioma, especially low-grade glioma (LGG). However,
the epileptogenic mechanisms are poorly understood. Recent evidence has indicated that …

The pathophysiological changes that occur after traumatic brain injury (TBI) can lead to the
development of post-traumatic epilepsy, a life-long complication of brain trauma. The …

Post-traumatic epilepsy is one of the most common and difficult to treat forms of acquired
epilepsy worldwide. Currently, there is no effective way to prevent post-traumatic …

Traumatic brain injury often leads to progressive alterations at the molecular to circuit levels
resulting in epilepsy and memory impairments. Ex vivo and in vitro models have provided a …

Electrophysiological experiments in the partial cortical isolation (“undercut” or “UC”) model
of injury-induced neocortical epileptogenesis have shown alterations in GABAergic synaptic …

Betz cells—the gigantopyramidal neurons found in high amount in the primary motor cortex—
are among of the most characteristic neuronal cells. A part of them contains the calcium …

Genetic variation accounts for much of the risk for developing a substance use disorder, but
the underlying genetic factors and their genetic effector mechanisms are mostly unknown …

Thrombospondins (TSPs) are astrocyte-secreted extracellular matrix proteins that play key
roles as regulators of synaptogenesis in the central nervous system. We previously showed …

Neocortical injury initiates a cascade of events, some of which result in maladaptive
epileptogenic reorganization of surviving neural circuits. Research focused on molecular …