The biophysical basis for phosphorylation-enhanced DNA-binding autoinhibition of the ETS1 transcription factor
C Perez-Borrajero, CSH Lin, M Okon, K Scheu… - Journal of molecular …, 2019 - Elsevier
The eukaryotic transcription factor ETS1 is regulated by an intrinsically disordered serine-
rich region (SRR) that transiently associates with the adjacent ETS domain to inhibit DNA …
rich region (SRR) that transiently associates with the adjacent ETS domain to inhibit DNA …
Conformational dynamics and the binding of specific and nonspecific DNA by the autoinhibited transcription factor Ets-1
G Desjardins, M Okon, BJ Graves, LP McIntosh - Biochemistry, 2016 - ACS Publications
The affinity of the Ets-1 transcription factor for DNA is autoinhibited by an intrinsically
disordered serine-rich region (SRR) and a helical inhibitory module (IM) appended to its …
disordered serine-rich region (SRR) and a helical inhibitory module (IM) appended to its …