Neoadjuvant chemotherapy (NAC) had been developed as a systematic approach before
definitive surgery for the treatment of locally advanced or inoperable breast cancer such as …

Triple-negative breast cancer (TNBC) is a special subtype of breast cancer, accounting for
10–20% of breast cancers with high intrinsic heterogeneity. Its unique immune …

Importance Approximately 25% of patients with early-stage breast cancer who receive (neo)
adjuvant chemotherapy experience a recurrence within 5 years. Improvements in therapy …

Inflammatory blood markers (IBM), such as the neutrophil to lymphocyte ratio (NLR), have
emerged as potential prognostic factors in various cancers, including breast cancer (BC) …

In recent years, the tumor microenvironment (TME) has been a research hotspot, as it is
composed of distinct cellular and non-cellular elements that may influence the diagnosis …

The interest in tumor-infiltrating lymphocytes (TILs) as a prognostic biomarker in breast
cancer has grown in recent years. Biomarkers must undergo comprehensive evaluation in …

Abstract Background Tumor-associated macrophages (TAMs) are associated with poor
outcomes in multiple solid cancers and play important roles in cancer progression. Epithelial …

Breast cancer has been one of the last tumor types to see benefit from immunotherapies.
Yet, immune infiltrates have been noticed for decades in primary breast cancers. Lately …

Background MKI67 plays a vital role in the tumour microenvironment (TME) and congenital
immunity. The present work focuses on exploring the prognosis prediction performance of …

High levels of histamine and histamine receptors (HRs), including H1R~ H4R, are found in
many different types of tumor cells and cells in the tumor microenvironment, suggesting their …