The granuloma, which is a compact aggregate of immune cells, is the hallmark structure of
tuberculosis. It is historically regarded as a host-protective structure that'walls off'the infecting …

Immune responses to Mycobacterium tuberculosis are only partially effective; they drive the
bacteria into a latent state, but rarely eliminate them. Unfortunately, the latent state of M …

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …

Mycobacterium tuberculosis is a highly successful pathogen that parasitizes the
macrophages of its host. Its success can be attributed directly to its ability to manipulate the …

Mycobacterium tuberculosis survives in antigen-presenting cells (APCs) such as
macrophages and dendritic cells. APCs present antigens in association with major …

Tuberculosis poses a significant threat to mankind. Multidrug-resistant strains are on the
rise, and Mycobacterium tuberculosis infection is often associated with human …

The tuberculosis vaccine Mycobacterium bovis bacille Calmette-Guérin (BCG) was
equipped with the membrane-perforating listeriolysin (Hly) of Listeria monocytogenes, which …

The variable efficacy of Bacille Calmette Guerin (BCG) vaccination against tuberculosis has
prompted efforts to improve the vaccine. In this study, we used autophagy to enhance …

▪ Abstract Phagocytosis and phagolysosome biogenesis represent fundamental biological
processes essential for proper tissue homeostasis, development, elimination of invading …

Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis (TB), is the current
leading cause of death due to a single infectious organism. Although curable, the broad …