Ligand-targeted delivery of photosensitizers for cancer treatment

P Gierlich, AI Mata, C Donohoe, RMM Brito, MO Senge… - Molecules, 2020 - mdpi.com
Photodynamic therapy (PDT) is a promising cancer treatment which involves a
photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which …

EGFR-targeted photodynamic therapy

L Ulfo, PE Costantini, M Di Giosia, A Danielli… - Pharmaceutics, 2022 - mdpi.com
The epidermal growth factor receptor (EGFR) plays a pivotal role in the proliferation and
metastatization of cancer cells. Aberrancies in the expression and activation of EGFR are …

[HTML][HTML] HSP90 inhibitor encapsulated photo-theranostic nanoparticles for synergistic combination cancer therapy

T Lin, W Guo, Q Long, A Ma, Q Liu, H Zhang… - Theranostics, 2016 - ncbi.nlm.nih.gov
Photodynamic therapy (PDT) is a promising non-invasive therapeutic modality that has been
proposed for treating prostate cancer, but the procedure is associated with limited efficacy …

Targeted photoimmunotherapy for cancer

A Mussini, E Uriati, P Bianchini, A Diaspro… - Biomolecular …, 2022 - degruyter.com
Photodynamic therapy (PDT) is a clinically approved procedure that can exert a curative
action against malignant cells. The treatment implies the administration of a photoactive …

Recent progress in chemical modifications of chlorophylls and bacteriochlorophylls for the applications in photodynamic therapy

J Staron, B Boron, D Karcz… - Current Medicinal …, 2015 - ingentaconnect.com
Since photodynamic therapy emerged as a promising cancer treatment, the development of
photosensitizers has gained great interest. In this context, the photosynthetic pigments …

Antibody-directed phototherapy (ADP)

H Pye, I Stamati, G Yahioglu, MA Butt, M Deonarain - Antibodies, 2013 - mdpi.com
Photodynamic therapy (PDT) is a clinically-approved but rather under-exploited treatment
modality for cancer and pre-cancerous superficial lesions. It utilises a cold laser or LED to …

Newest approaches to singlet oxygen photosensitisation in biological media

O Planas, E Boix-Garriga, B Rodríguez-Amigo, J Torra… - 2014 - books.rsc.org
Production of singlet molecular oxygen by photosensitisation remains the most common and
convenient means of producing this non-radical yet highly-reactive oxygen species that …

Synthesis of 3, 20-disubstituted chlorophyll-a derivatives and reactivity of the substituents

H Tamiaki, N Ariki, H Sugiyama, Y Taira, Y Kinoshita… - Tetrahedron, 2013 - Elsevier
Abstract Methyl 20-bromo-pyropheophorbide-a possessing a vinyl group at the 3-position
and its analogs having 3-ethyl, 3-(1-hydroxyethyl) and 3-acetyl groups were prepared by …

[HTML][HTML] Upregulation of mucin glycoprotein MUC1 in the progression to esophageal adenocarcinoma and therapeutic potential with a targeted photoactive antibody …

MA Butt, H Pye, RJ Haidry, D Oukrif, I Puccio… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Background Mucin glycoprotein 1 (MUC1) is a glycosylated transmembrane protein on
epithelial cells. We investigate MUC1 as a therapeutic target in Barrett's epithelium (BE) and …

A HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy

H Pye, MA Butt, HW Reinert, A Maruani… - Photochemical & …, 2016 - Springer
In many cancers early intervention involves surgical resection of small localised tumour
masses. Inadequate resection leads to recurrence whereas overzealous treatment can lead …