The classical view that only adaptive immunity can build immunological memory has
recently been challenged. Both in organisms lacking adaptive immunity as well as in …

Innate immune cells can develop exacerbated immunologic response and long-term
inflammatory phenotype following brief exposure to endogenous or exogenous insults …

Induction of trained immunity (innate immune memory) is mediated by activation of immune
and metabolic pathways that result in epigenetic rewiring of cellular functional programs …

Acute tubular necrosis (ATN) caused by ischemia/reperfusion (I/R) during renal
transplantation delays allograft function. Identification of factors that mediate protection …

Hydrogen sulfide (H 2 S) is a toxic gas and one of the air pollutants of great concern. High-
concentrated H 2 S can induce energy metabolism disturbance and apoptosis. However, the …

Mitochondria are cellular organelles that control metabolic homeostasis and ATP
generation, but also play an important role in other processes, like cell death decisions and …

Diabetes is a major stroke risk factor and is associated with poor functional recovery after
stroke. Accumulating evidence indicates that the worsened outcomes may be due to …

Oxygen is a vital element in aquatic environments. The concentration of oxygen to which
aquatic organisms are exposed is influenced by salinity, water temperature, weather, and …

β-Glucan derived from cell walls of Candida albicans is a potent immune modulator. It has
been shown to induce trained immunity in monocytes via epigenetic and metabolic …

Cells must continuously monitor and couple their metabolic requirements for ATP utilization
with their ability to take up O2 for mitochondrial respiration. When O2 uptake and delivery …