Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease characterized by
autoimmune destruction of pancreatic β cells. Transplantation of immunoisolated pancreatic …

The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …

Intrahepatic islet transplantation is the standard cell therapy for β cell replacement. However,
the shortage of organ donors and an unsatisfactory engraftment limit its application to a …

Diabetes is one of the most socially challenging health concerns. Even though islet
transplantation has shown promise for insulin-dependent diabetes, there is still no effective …

Endothelial cells (ECs) are a key cellular component of the vascular system as they form the
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …

Intrahepatic islet transplantation is a promising β-cell replacement strategy for the treatment
of type 1 diabetes. Instant blood-mediated inflammatory reactions, acute inflammatory storm …

Pancreatic in vitro research is of major importance to advance mechanistic understanding
and development of treatment options for diseases such as diabetes mellitus. We present a …

Aims The extracellular matrix (ECM) is fundamental for the normal endocrine functions of
pancreatic islet cells and plays key roles in the pathophysiology of type 2 diabetes. Here we …

Transplantation of islets of Langerhans is a promising alternative treatment strategy in
severe cases of type 1 diabetes mellitus; however, the success rate is limited by the survival …

Progress in diabetes research is hindered, in part, by deficiencies in current experimental
systems to accurately model human pathophysiology and/or predict clinical outcomes …