Small molecule selenium-containing compounds: Recent development and therapeutic applications

H Chuai, SQ Zhang, H Bai, J Li, Y Wang, J Sun… - European Journal of …, 2021 - Elsevier
Selenium (Se) is an essential micronutrient of organism and has important function. It
participates in the functions of selenoprotein in several manners. In recent years, Se has …

Selenium as an emerging versatile player in heterocycles and natural products modification

W Hou, H Dong, X Zhang, Y Wang, L Su, H Xu - Drug Discovery Today, 2022 - Elsevier
The diverse pharmacological activities of organoselenium compounds are closely correlated
to their ability to scavenge and induce reactive oxygen species (ROS), their intrinsic …

Incorporating selenium into heterocycles and natural products─ from chemical properties to pharmacological activities

W Hou, H Xu - Journal of Medicinal Chemistry, 2022 - ACS Publications
Selenium (Se)-containing compounds have emerged as potential therapeutic agents for the
treatment of a range of diseases. Through tremendous effort, considerable knowledge has …

Recent developments in the synthesis of biologically relevant selenium-containing scaffolds

B Banerjee, M Koketsu - Coordination Chemistry Reviews, 2017 - Elsevier
Recent, many methods have been reported for the synthesis of selenium-containing
bioactive scaffolds because of their interesting reactivity and potential pharmaceutical …

Introducing alkyl selenocyanates as bifunctional reagents in photoredox catalysis: Divergent access to ambident isomers of− SeCN

S Pramanik, AK Das, S Debnath, S Maity - Organic Letters, 2024 - ACS Publications
Owing to their diverse biological activities and versatility as synthetic precursors,
organoselonocyanes categorize themselves as vital compounds. However, a limited reagent …

Apoptotic, necrotic, and antiproliferative activity of diosgenin and diosgenin glycosides on cervical cancer cells

JMV Hernández-Vázquez, H López-Muñoz… - European Journal of …, 2020 - Elsevier
Abstract (25R)-spirost-5-en-3β-ol, also known as diosgenin (DSG), exerts antiproliferative
activity on diverse cell lines, induces apoptosis, and acts as a chemopreventative agent …

Novel heteroaryl selenocyanates and diselenides as potent antileishmanial agents

Y Baquedano, V Alcolea, MÁ Toro… - Antimicrobial agents …, 2016 - Am Soc Microbiol
ABSTRACT A series of new selenocyanates and diselenides bearing interesting bioactive
scaffolds (quinoline, quinoxaline, acridine, chromene, furane, isosazole, etc.) was …

(1-Selenocyanatoethyl)benzene: A Selenocyanation Reagent for Site-Selective Selenocyanation of Inert Alkyl C(sp3)–H Bonds

F Yu, C Li, C Wang, H Zhang, ZY Cao - Organic Letters, 2021 - ACS Publications
A new, simple, yet easily accessible,(1-selenocyanatoethyl) benzene has been designed
and applied as a SeCN group transfer reagent for selenocyanation of aliphatic C (sp3)–H …

Visible-Light-Driven Bifunctional Photocatalytic Radical-Cascade Selenocyanation/Cyclization of Acrylamides with KSeCN

X Ren, T Zhang, B Wang, W Jin, Y Xia… - The Journal of …, 2024 - ACS Publications
A visible-light-induced radical-cascade selenocyanation/cyclization of N-alkyl-N-
methacryloyl benzamides, 2-aryl-N-acryloyl indoles, and N-methacryloyl-2 …

Diosgenin-based thio (seleno) ureas and triazolyl glycoconjugates as hybrid drugs. Antioxidant and antiproliferative profile

LL Romero-Hernandez, P Merino-Montiel… - European Journal of …, 2015 - Elsevier
The stereoselective preparation of diosgenin-derived thio (seleno) ureas and glycomimetics
bearing a 1, 2, 3-triazolyl tether on C-3 has been accomplished. The key steps in the …