Abstract Background The Wnt signaling pathway is a complex network of protein interactions
that functions most commonly in embryonic development and cancer, but is also involved in …

We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

The corpus callosum (CC) connects the cerebral hemispheres and is the major mammalian
commissural tract. It facilitates bilateral sensory integration and higher cognitive functions …

Thermogenesis is an important contributor to whole-body energy expenditure and metabolic
homeostasis. Although circulating factors that promote energy expenditure are known …

Growing axons are exposed to various guidance cues en route to their targets. Although
many guidance molecules have been identified and their effects on axon behavior …

Background 'Long read'sequencing methods have been used to identify previously
uncharacterized structural variants that cause human genetic diseases. Therefore, we …

Early-life stress (ELS) is known to be associated with an increased risk of neuropsychiatric
and cardiometabolic disease in later life. One of the potential mechanisms underpinning this …

Abstract Tsukushi (TSK), a leucine-rich peptidoglycan in the extracellular compartment,
mediates multiple signaling pathways that are critical for development and metabolism. TSK …

microRNA-2110 (miR-2110) was previously identified as inducing neurite outgrowth in a
neuroblastoma cell lines BE (2)-C, suggesting its differentiation-inducing and …

Abstract Tsukushi (TSK)—a small, secreted, leucine-rich-repeat proteoglycan—interacts with
and regulates essential cellular signaling cascades. However, its functions in the mouse …