Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Metal ions play significant roles in numerous fields including chemistry, geochemistry,
biochemistry, and materials science. With computational tools increasingly becoming …

Chemical modifications of RNA provide an additional, epitranscriptomic, level of control over
cellular functions. N-6-methylated adenosines (m6As) are found in several types of RNA …

The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) support the
survival and functioning of various neuronal populations. Thus, they could be attractive …

The first edition of this book, Chemical Warfare Agents: Toxicity at Low Levels, was
published just prior to the terrorist attacks of September 11th, 2001. Reflecting a greater …

One-pot sequences of hydrogenation/hydroamination to form indoles from (2-nitroaryl)
alkynes and hydrogenation/reductive amination to form aniline derivatives from nitroarenes …

The potential for the use of Clostridial neurotoxins as bioweapons makes the development
of small-molecule inhibitors of these deadly toxins a top priority. Recently, screening of a …

Botulinum neurotoxins (BoNTs), etiological agents of the deadly food poisoning disease
botulism, are the most toxic proteins currently known. By using in situ lead identification …

Zn2+ is one of the most versatile biologically available metal ions, but accurate modeling of
Zn2+‐containing metalloproteins at the biomolecular force field level can be challenging …

Among the agents classified as “Category A” by the US Centers for Disease Control and
Prevention, botulinum neurotoxin (BoNT) is the most toxic protein known, with microgram …