Inhibitors of c-Jun N-terminal kinases: an update
The c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the
pathogenesis of various diseases. Recent advances in the development of novel inhibitors …
pathogenesis of various diseases. Recent advances in the development of novel inhibitors …
Computational identification of potential anti-inflammatory natural compounds targeting the p38 mitogen-activated protein kinase (MAPK): Implications for COVID-19 …
Severely ill coronavirus disease 2019 (COVID-19) patients show elevated concentrations of
pro-inflammatory cytokines, a situation commonly known as a cytokine storm. The p38 …
pro-inflammatory cytokines, a situation commonly known as a cytokine storm. The p38 …
Stereoselective synthesis of tetrahydrofuran lignans
D Soorukram, M Pohmakotr, C Kuhakarn… - Synthesis, 2018 - thieme-connect.com
This short review aims to summarize the reports on stereoselective synthesis of naturally
occurring tetrahydrofuran lignans published during the period of 2006 to 2018. The …
occurring tetrahydrofuran lignans published during the period of 2006 to 2018. The …
Polarizable force fields for biomolecular modeling
This chapter focuses on the recent developments in different polarizable force fields. These
include atomic multipole optimized energetics for biomolecular applications (AMOEBA), sum …
include atomic multipole optimized energetics for biomolecular applications (AMOEBA), sum …
Arrestin-3 binds c-Jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding
Non-visual arrestins scaffold mitogen-activated protein kinase (MAPK) cascades. The c-Jun
N-terminal kinases (JNKs) are members of MAPK family. Arrestin-3 has been shown to …
N-terminal kinases (JNKs) are members of MAPK family. Arrestin-3 has been shown to …
Design, synthesis and biological evaluation of fused naphthofuro [3, 2-c] quinoline-6, 7, 12-triones and pyrano [3, 2-c] quinoline-6, 7, 8, 13-tetraones derivatives as …
AA Aly, EM El-Sheref, MEM Bakheet, MAE Mourad… - Bioorganic …, 2019 - Elsevier
Approximately 60% of human cancers exhibit enhanced activity of ERK1 and ERK2,
reflecting their multiple roles in tumor initiation and progression. Acquired drug resistance …
reflecting their multiple roles in tumor initiation and progression. Acquired drug resistance …
Synthesis of novel 1, 2-bis-quinolinyl-1, 4-naphthoquinones: ERK2 inhibition, cytotoxicity and molecular docking studies
AA Aly, EM El-Sheref, MEM Bakheet, MAE Mourad… - Bioorganic …, 2018 - Elsevier
Two novel series of N-2, 3-bis (6-substituted-4-hydroxy-2-oxo-1, 2-dihydroquinolin-3-yl)
naphthalene-1, 4-diones 3a-d and substituted N-(methyl/ethyl) bisquinolinone triethyl …
naphthalene-1, 4-diones 3a-d and substituted N-(methyl/ethyl) bisquinolinone triethyl …
[HTML][HTML] Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf
R Samadani, J Zhang, A Brophy, T Oashi… - The Biochemical …, 2015 - ncbi.nlm.nih.gov
Constitutive activation of the extracellular-signal-regulated kinases 1 and 2 (ERK1/2) are
central to regulating the proliferation and survival of many cancer cells. The current inhibitors …
central to regulating the proliferation and survival of many cancer cells. The current inhibitors …
Development of 2′-aminospiro [pyrano [3, 2–c] quinoline]-3′-carbonitrile derivatives as non-ATP competitive Src kinase inhibitors that suppress breast cancer cell …
Src kinase activity controls diverse cellular functions, including cell growth, migration,
adhesion, and survival. It is de-regulated in several cancers, including breast cancer, where …
adhesion, and survival. It is de-regulated in several cancers, including breast cancer, where …
Stereoselective Sequential Spirocyclopropanation/Cloke–Wilson Rearrangement Reactions for Synthesis of trans-β,γ-Disubstituted γ-Butyrolactones Using …
M Zhang, T Li, C Cui, X Song… - The Journal of Organic …, 2020 - ACS Publications
The stereoselective sequential spirocyclopropanation/Cloke–Wilson rearrangement
reactions have been developed to synthesize γ-butyrolactones using alkylidene Meldrum's …
reactions have been developed to synthesize γ-butyrolactones using alkylidene Meldrum's …