Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

There is substantial evidence that growth and remodeling of load bearing soft biological
tissues is to a large extent controlled by mechanical factors. Mechanical homeostasis, which …

In response to tissue injury, fibroblasts differentiate into professional repair cells called
myofibroblasts, which orchestrate many aspects of the normal tissue repair programme …

Cardiac fibroblasts and their activated derivatives, myofibroblasts, play a critical role in
wound healing after myocardial injury and often contribute to long-term pathological …

Pulmonary arterial stiffness is an independent risk factor for mortality in pulmonary
hypertension (PH) and plays a critical role in PH pathophysiology. Our laboratory has …

Mechanical stretch is widely experienced by cells of different tissues in the human body and
plays critical roles in regulating their behaviors. Numerous studies have been devoted to …

Aortic valve stenosis (AVS) patients experience pathogenic valve leaflet stiffening due to
excessive extracellular matrix (ECM) remodeling. Numerous microenvironmental cues …

Cells dynamically assemble and organize into complex tissues during development, and the
resulting three-dimensional (3D) arrangement of cells and their surrounding extracellular …

Background Myofascial Pain Syndrome (MPS) is a common, overlooked, and
underdiagnosed condition and has significant burden. MPS is often dismissed by clinicians …

Hepatic stellate cells (HSCs) are one of the primary drivers of liver fibrosis in non-alcoholic
fatty liver disease. Although HSC activation in liver disease is associated with changes in …