Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L.
and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein …

MPS disorders are associated with a wide spectrum of neurocognitive effects, from mild
problems with attention and executive functions to progressive and degenerative …

Mucopolysaccharidosis type IIIA is a severe degenerative disease caused by an autosomal
recessive defect of a gene encoding a lysosomal heparan-N-sulfamidase, the N …

Over the past several years the number of treatments available for patients with lysosomal
storage disorders has rapidly increased. Haematopoietic stem cell transplantation, enzyme …

A balanced metabolic profile is essential for normal human physiological activities.
Disproportions in nutrition give rise to imbalances in metabolism that are associated with …

Neurodegenerative diseases are caused by the progressive loss of function or structure of
nerve cells in the central nervous system. The most common neurodegenerative diseases …

Abstract Mucopolysaccharidosis type III (MPS III, Sanfilippo syndrome) is a lysosomal
storage disorder, caused by a deficiency in one of the four enzymes involved in the …

The majority of lysosomal storage diseases affect the brain. Treatment of the brain with
intravenous enzyme replacement therapy is not successful, because the recombinant …

Background Flavonoids and saponins are important bioactive compounds that have
attracted wide research interests. This review aims to summarise the state of the art of the …

During the past decades, several therapeutic approaches have been developed and made
rapidly available for many patients afflicted with lysosomal storage disorders (LSDs), inborn …