Benzenes, the most ubiquitous structural moiety in marketed small-molecule drugs, are
frequently associated with poor 'drug-like'properties, including metabolic instability, and poor …

Three-and four-membered rings, widespread motifs in nature and medicinal chemistry, have
fascinated chemists ever since their discovery. However, due to energetic considerations …

Bridged bicyclic scaffolds are emerging bioisosteres of planar aromatic rings under the
concept of “escape from flatland”. However, adopting this concept into the exploration of …

Saturated nitrogen heterocycles are among the most significant structural components in
small-molecule pharmaceuticals. Herein, a protocol for the construction of enantiopure 2 …

N-Heterocyclic carbenes (NHCs) are cyclic carbenes bearing at least one R-amino
substituent. 1 The most common subclasses of NHCs are represented in Chart 1. Early work …

Allenes have always fascinated chemists because of the intriguing features of the cumulated
diene function such as the higher reactivity compared to simple alkenes and the peculiar …

A general approach to 3‐azabicyclo [3.1. 1] heptanes by reduction of spirocyclic oxetanyl
nitriles was developed. The mechanism, scope, and scalability of this transformation were …

The strong σ-donor but poor π-acceptor abilities of N-heterocyclic carbenes (NHCs) result in
chemical stability and coordination versatility, thus allowing them to coordinate with many …

Methylene-and alkylidenecyclopropanes (MCPs and ACPs, 1, Figure 1) and-cyclobutanes
(MCBs and ACBs, 2, Figure 1) are highly strained molecules, but at the same time most of …

The allene moiety represents an excellent partner for the [2+ 2] cycloaddition with alkenes
and alkynes, affording the cyclobutane and cyclobutene skeletons in a single step. This …