In each generation, the germline is tasked with producing somatic lineages that form the
body, and segregating a population of cells for gametogenesis. During animal development …

Mammalian primordial germ cells (PGCs) are induced in the embryonic epiblast, before
migrating to the nascent gonads. In fish, frogs, and birds, the germline segregates even …

The genetic, endocrine, and metabolic mechanisms underlying female reproduction are
numerous and sophisticated, displaying complex functional evolution throughout a woman's …

Bone marrow mesenchymal stem cells (BMSCs), which are well characterized and widely
utilized adult stem cells, encompass the capacity to commit to a variety of cell types. This …

Mammalian germ cells are derived from primordial germ cells (PGCs) and ensure species
continuity through generations. Unlike irreversible committed mature germ cells, migratory …

During the early development of Placentalia, a distinctive projection emerges at the posterior
embryonic–extraembryonic interface of the conceptus; its fingerlike shape presages …

Human oogenesis is a highly complex and not yet fully understood process due to ethical
and technological barriers that limit studies in the field. In this context, replicating female …

Embryonic development is precisely regulated by a network of signal pathways and specific
genes. Dppa3 (also known as Pgc7 or Stella) plays an important role in early embryonic …

Hypoblast/visceral endoderm assists in amniote nutrition, axial positioning and formation of
the gut. Here, we provide evidence, currently limited to humans and non-human primates …

The ovary functions to chaperone the most precious cargo for female individuals, the oocyte,
thereby allowing the passage of genetic material to subsequent generations. Within the …