Coumarin heterocyclic derivatives: chemical synthesis and biological activity - Natural Product
Reports (RSC Publishing) DOI:10.1039/C4NP00162A Royal Society of Chemistry View PDF …

Benzimidazoles are the fused heterocyclic ring systems which form an integral part of
vitamin B 12 and have been luring many researchers all over the world to assess their …

Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …

Cancer is one of the most serious medical problem and second leading cause of death in
the world, characterized by a deregulation of the cell cycle which mainly results in a …

Sirtuins (SIRTs) catalyze the NAD+-dependent deacetylation of N ε-acetyl lysines on various
protein substrates. SIRTs are interesting drug targets as they are considered to be related to …

This review presents the detailed account of factors leading to cancer and design strategy
for the synthesis of benzimidazole derivatives as anticancer agents. The recent survey for …

Sirtuins are a family of NAD+-dependent deacetylases (class III histone deacetylases).
Seven mammalian sirtuins, SIRT1-7, are identified, as the functions and locations differ …

Histone deacetylases (HDAC) and histone deacetylase inhibitors (HDACi) have greatly
impacted the war on cancer. Their role in epigenetics has significantly altered the …

Out of several heterocyclic templates, the use of a Benzimidazole (BZ) scaffold is immensely
observed. This fused heterocycle comprises two ring nitrogen atoms placed at 1st and 3rd …

Abstract Sets of 3-alkenyl-2-oxindoles (6, 10, 13) were synthesized in a facile synthetic
pathway through acid dehydration (EtOH/HCl) of the corresponding 3-hydroxy-2 …