Herein, 2, 3-dioxo-1, 2, 3, 4-tetrahydroquinoxaline was used as a bio-isosteric scaffold to the
phthalazinone motif of the standard drug Olaparib to design and synthesize new derivatives …

Azaindole-1-carboxamides were designed as a new class of PARP-1 inhibitors. The
compounds displayed a variable pattern of target inhibition profile that, in part, paralleled the …

Epidermal growth factor receptor (EGFR) is the first growth factor receptor proposed as a
target for cancer therapy. Molecular modeling protocols like molecular docking, molecular …

Abstract Poly (ADP-ribose) polymerase-I (PARP-1) enzyme is involved in maintaining DNA
integrity and programmed cell death. A virtual screening of commercial libraries led to the …

US10414752B2 - Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate
dehydrogenase inhibitors - Google Patents US10414752B2 - Pyridin-2(1H)-one …

Abstract Janus kinase 1 (JAK 1) belongs to the JAK family of intracellular nonreceptor
tyrosine kinase. JAK-signal transducer and activator of transcription (JAK-STAT) pathway …

5, 262, 564 A 9, 073, 941 B2 9, 624, 175 B2 9, 624, 216 B2 9, 771, 349 B2 9, 815, 817 B2 9,
834, 539 B2 10, 005, 734 B2* 2014/0235620 A1 2016/0083349 Al 2016/0083365 A1 …

2016-08-08 Assigned to FORMA THERAPEUTICS, INC. reassignment FORMA
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

2284325 C2 9/2006 WO-2006/054912 A15/2006 WO-2007/117778 A2 10/2007
WO2011/072174 6/2011 WO2013/102431 7/2013 WO2014/141153 9/2014 WO …

Abstract Janus kinase 1 (JAK 1) plays a critical role in initiating responses to cytokines by
the JAK—signal transducer and activator of transcription (JAK-STAT). This controls survival …