Abacavir (ABC) is a carbocyclic 2′-deoxyguanosine nucleoside reverse transcriptase
inhibitor specifically prescribed for the treatment of HIV infection. However, as a BCS class III …

Ischemic heart disease (IHD) is a serious threat to human health due to its high incidence,
high mortality and difficult treatment. Tanshinone II A (Tan II A), a significant traditional …

Numerous hydrophobic compounds are important ingredients for drug discovery and
development. Hydrophobicity has been a major hurdle limiting the therapeutic efficacy of …

We investigated the solubility–permeability interplay using a solubilizer additive under non-
sink conditions. Sodium lauryl sulfate (SLS) was used as a solubilizer additive. The solubility …

Objectives In this research paper, an investigation has been made to assess the
simultaneous effect of a solubility enhancement approach, ie, hydrotropy on the solubility …

The objectives of this work are (1) To scrutinize the various hydrotropes for acting as
cinnarizine solubility augmenting excipient,(2) To show the existence of solubility …

The amorphous form of carvedilol phosphate (CVD) was obtained as a result of grinding.
The identity of the obtained amorphous form was confirmed by powder X-ray diffraction …

Background: Solubility/dissolution is said to be the key factor that influences the oral
bioavailability of drug and is also the rate limiting step in formulation development …

The primary goal of drug formulation is to improve a drug's bioavailability in the body.
However, poorly water-soluble drugs present challenging issues related to their solubility …

Solubility, a critical parameter governing the bioavailability and therapeutic efficacy of
pharmaceutical compounds, often poses a significant challenge in drug development. This …